The Canadian astronaut was joined by NASA astronaut Anne McClain and Russian cosmonaut Oleg Kononenko aboard a Soyuz capsule that landed in Kazakhstan.
In a press release issued by the United States space agency, during their mission the three orbited Earth 3,264 times and travelled 88,430,555 miles.
Nasa astronaut Anne McClain, veteran cosmonaut Oleg Kononenko of Roscosmos, and Canadian Space Agency record-holder David Saint-Jacques emerged from the space craft to applause from support crews, after touching down near the Kazakh city of Dzhezkazgan.
The first crew to blast off to the International Space Station following a launch accident that deepened doubts over Russia's space programme is set to return to earth Tuesday.
McClain, the NASA astronaut, and Saint-Jacques, of the Canadian Space Agency, will be wrapping up their first trips to space.
Saint-Jacques' mission began ahead of schedule on December 3, when he was part of the first crewed Soyuz mission following a rocket mishap in October that forced a spacecraft carrying two astronauts to abort and make an emergency landing. The trio touched down inside the Russian-built Soyuz capsule.
In the next few months, the returning crew members will undergo a number of tests, as scientists continue to study how microgravity affects the human body.
Meanwhile McClain, a native of Spokane, Washington, conducted two spacewalks that clocked in at a total of 13 hours and 8 minutes, the agency added. During one of her spacewalks, McClain was joined by Saint-Jacques, who became only the sixth Canadian to venture outside the space station.
As soon as the departing trio's ride left the space station's docking port, Expedition 60 commenced inside ISS.
When their Soyuz MS-11 spacecraft undocked at 7:25 p.m., Expedition 60 began aboard the station officially, with Nick Hague and Christina Koch of NASA as flight engineers, and Alexey Ovchinin of Roscosmos as the station's commander.
Nasa said earlier this month that it will be opening the ISS up to space tourists for the first time next year with 30-day visits expedited by SpaceX and Boeing expected to cost around $58 million per person.