Terry Leavitt had brought on the lawsuit against J&J and said she used the company's Baby Powder and Shower to Shower in the 1960s and 1970s and was diagnosed with mesothelioma in 2017, Reuters reported.
In July a year ago, J&J was ordered to pay $4.7 billion to 22 ovarian cancer patients by a court in the U.S. state of Missouri.
Johnson & Johnson is facing over 13,000 more cases stemming from asbestos-contaminated talcum powder.
The company also noted that multiple cases have been decided in favor of J&J, or been declared mistrials.
Johnson & Johnson must pay about $29 million to a dying California woman who blamed asbestos-tainted talc for causing her cancer, the company's latest loss in nationwide litigation over its iconic baby powder.
J&J says its products do not contain asbestos, and said it will appeal Wednesday's jury decision.
'Yet another jury has rejected J&J´s misleading claims that its talc was free of asbestos, ' said Moshe Maimon, a lawyer for Leavitt, in a statement on Wednesday.
"We respect the legal process and reiterate that jury verdicts are not medical, scientific or regulatory conclusions about a product", Johnson & Johnson said in a statement.
J&J said it was disappointed with the verdict and would appeal, citing "serious procedural and evidentiary errors" in the course of the trial.
Even though Leavitt stopped using baby powder two decades ago, recent tests of her lung tissue showed evidence of asbestos, an expert witness testifying for the plaintiff told jurors at one point in the trial.
The US Food and Drug Administration had commissioned a study of a variety of talc samples, including Johnson & Johnson's, from 2009 to 2010.
Amid the scrutiny, Reuters late past year published a report alleging that J&J knew about asbestos in its talc for decades.
Leavitt's is the first case to go to trial since a December Reuters report based on internal documents confirmed Johnson & Johnson was aware the talc in its products sometimes contained asbestos from the 1970s up until the early 2000s, but failed to inform consumers or regulators of that fact. When asbestos fibers are breathed in, they travel to the ends of small air passages and reach the membranes of the thorax and lunges.