A host of pundits accused Ireland of lacking a Plan B in the wake of last weekend's 32-20 physical battering at the hands of England.
In the backline, centre Chris Farrell will make his first Six Nations start, while fullback Rob Kearney replaces Robbie Henshaw, who has fallen out of the match 23.
Ahead of tomorrow's 2.15pm kick-off in BT Murrayfield, we are asking you to select the best combined XV from the two starting line-ups in the poll below.
Munster powerhouse Farrell will partner Bundee Aki in midfield, with Robbie Henshaw dropping out of Ireland's match squad due to a dead leg.
Farrell was selected after Garry Ringrose, who played against England, was ruled out with a hamstring injury.
The only other change sees Sean O'Brien favoured over Leinster teammate Josh van der Flier at flanker. It's a knock on top of a knock. He stepped in only once past year and got man of the match.
"It's massive", captain Rory Best said of losing Toner on Friday. Joe Schmidt said. "It's a pretty exciting opportunity to give Chris Farrell the chance to play against Scotland". Roux failed to make the cut for Ireland's initial Six Nations squad, but has since leapfrogged provincial team-mate Ultan Dillane, who takes a seat on the bench.
Toner is the third Ireland lock lost to injury after Iain Henderson and Tadhg Beirne.