Netanyahu's interrogation took place two days before the planned start of his wife's trial, who is accused of fraudulently obtaining funding from the prime minister's office to order hundreds of meals from restaurants, worth more than 350,000 new shekels (about 97,000 USA dollars).
According to her charge sheet, she fraudulently obtained some 100,000 USA dollars of public funds for hundreds of meals supplied by well-known restaurants and chefs to the official Prime Minister's Residency in Jerusalem while falsely stating that there were no cooks or staff at home.
The wife of the Israeli prime minister went on trial in Jerusalem yesterday for fraud and embezzlement, following allegations that she spent £75,000 of taxpayers' money on food prepared by celebrity chefs.
In case of recognition guilty, the wife of the Israeli Prime Minister can spend in prison till five years, however, this verdict seems unlikely.
She was also charged with fraud and breach of trust and of aggravated fraudulent receipt of goods.
Sara Netanyahu has previously been accused of pocketing cash from deposit refunds for empty bottles returned from the official residence. Her attorneys have said she did not know she was violating the rules.
Police questioned Prime Minister Netanyahu for several hours on Friday as part of investigations into alleged corruption by the long-serving premier. The residence's former deputy director was also indicted in the case.
In that case, Benjamin Netanyahu is alleged to have sought favourable coverage from another Elovitch company, the Walla news site, in exchange for government policies that could have benefited the mogul's interests to the tune of hundreds of millions of dollars.
Mr Netanyahu, who has allied himself to US President Donald Trump, has long portrayed himself as the only politician able to keep Israel safe from its enemies at home and overseas.
In recent years, as Israel's public shifted more to the right, the more liberal opposition has struggled to regain pockets of power.
Despite the ongoing investigations, Netanyahu has remained strong in polls and he is not obliged to step down if formally charged.
Mr Netanyahu said the claims against his wife are "baseless and delusional".