If confirmed, Judge Kavanaugh would tip the balance on the court to a 5-4 majority in favour of conservatives in possible legal battles ahead over contentious issues such as abortion rights, immigration, and Mr Trump's attempt to ban transgender people from the USA military. He said he would return to cast the decisive vote if needed.
Kavanaugh was sworn in as a justice Saturday evening in Washington after an extraordinarily fraught nomination that sparked angry protests, nail-biting votes and a national reckoning about sexual assault allegations and who should be believed.
The path to Kavanaugh's confirmation cleared on Friday when two wavering Republicans, Susan Collins of ME and Jeff Flake of Arizona, said they would vote for Kavanaugh after concluding that Ford's allegations, voiced by her in an emotional hearing last week, could not be corroborated.
Mr Trump, himself accused by numerous women during the 2016 presidential election of sexual misconduct, tweeted his approval for yesterday's Senate vote, saying, "Very proud of the US Senate for voting "YES" to advance the nomination of Judge Brett Kavanaugh!".
Attorneys for Christine Blasey Ford say their client is not interested in murmurings that Democrats may seek to impeach Judge Brett Kavanaugh if they reclaim the House of Representatives in the November midterm elections.
Daines, a Montana Republican who has supported Kavanaugh's nomination, has been scheduled to attend his daughter's wedding on Saturday for months and made it clear he wouldn't be skipping the ceremony. "It's just not worth it".
Republicans "conducted one of the least transparent, least fair, most biased processes in Senate history, slanting the table from the very beginning to produce their desired result", he added.
For Murkowski, the vote marked the second time she bucked party leadership on a high-profile issue under President Donald Trump.
As Manchin addressed the media after making his announcement, protesters shouted over him in anger: "Look at us".
Republican Lisa Murkowski of Alaska, a fellow moderate and a friend of Collins, became the only Republican to say she opposed Kavanaugh. In fact, they leaked it to so many journalists that reporters showed up at her home and her classroom seeking to interview her.
"This started out as a debate over judicial philosophy - now it's turned into a referendum on the me too movement - galvanizing women who see it as a reflection of their own experiences with sexual harassment".
Kavanaugh's confirmation vote is scheduled to begin at 3:30 p.m. on Saturday.
Majority Leader Mitch McConnell described Kavanaugh as a "superstar".
"Laura and I have known and respected Brett Kavanaugh for decades, and we stand by our comments the night Judge Kavanaugh was nominated", he said in September in a statement provided to CNN by his spokesperson, Freddy Ford. Kirsten Gillibrand, one of the Democrats who take to the Senate floor early Saturday to rail against Kavanaugh. "He's clearly a learned judge".
How do I know it was Democrats who leaked her letter? Ford had accused Kavanaugh of sexually assaulting her in 1982 when they both were in high school.
Collins insisted that her procedural vote for Kavanaugh in the morning had nothing to do with the decision she made in the afternoon, which was delivered through her floor speech and dispersed in writing to inboxes soon after that. Flake demanded the limited FBI investigation last week after being cornered in an elevator by screaming protesters moments before a Senate Judiciary Committee vote to recommend Kavanaugh's nomination. They said he also seemed ready to rule for Trump if federal authorities probing his 2016 campaign's connections to Russian Federation try to pursue him in court. However, based on all of the information I have available to me, including the recently completed Federal Bureau of Investigation report, I have found Judge Kavanaugh to be a qualified jurist who will follow the Constitution and determine cases based on the legal findings before him.