The gaffe-prone Johnson was quickly replaced by 51-year-old former health minister Jeremy Hunt, who unlike Johnson supported staying in the European Union in the 2016 referendum.
May met with Conservative lawmakers in a packed room at Parliament, in a bid to calm the feverish atmosphere in the deeply divided party. Jacob Rees-Mogg, who leads a bloc of Brexit-supporting Conservative MPs in Parliament, urged May to give up on the plan.
The tousle-headed blond Johnson is one of Britain's best-known politicians, and one of the most prominent advocates for Brexit.
Tory MPs can trigger a vote of no confidence if 48 of them submit letters to the 1922 backbencher committee, chaired by Sir Graham Brady. "The dream is dying, suffocated by needless self-doubt", he wrote.
"I can tell you that it is crystal clear at the end of this negotiation, that the best situation, with the best relationship with the European Union, will remain to be a member of the European Union".
"What Theresa May was trying to do with her proposal last week was to come up with a compromise that would keep all sides on ball within the Conservative party, and clearly that has failed", Clark said.
British journalist and writer Neil Clark told RT how there is now "incredible uncertainty" over how the United Kingdom will go about Brexit negotiations, given a "split" in the party over the country's future trade relations with the EU.
Government unity began to fray within hours.
The Sun, Britain's biggest-selling newspaper, said there had been "blunder after blunder" by May.
And in a rather dramatic fashion, news broke mid-way through the interview.
May defended her Brexit plan to lawmakers in the House of Commons on Monday, with Johnson absent from his usual place on the Conservative front bench. They also argued that the proposals breach several of the "red lines" that the government had set out, including a commitment to leave the EU's tariff-free customs union.
While International Development Secretary Penny Morduant immediately welcomed the decision saying Rabb is "highly capable, across the issues, attention to detail, Leave supporter and pragmatist", others said Davis' resignation has plunged Britain into "absolute chaos".
Newly appointed Brexit secretary Dominic Raab.