South Africans demonstrated in solidarity with Palestinians on Tuesday, a day after 60 were killed protesting the USA embassy's move to Jerusalem, with anti-apartheid icon Archbishop Desmond Tutu declaring himself "brokenhearted".
Ireland has called for an independent global investigation into the deaths, with the United Nations taking the lead.
"Our mission in Ramallah reports that emergency responders in Gaza and the strip's health services are overwhelmed with the level of casualties", he said. The World Health Organisation (WHO) has reported 211 attacks on those attending to the injured during mass demonstration at the border fence.
The death toll led to strong condemnation from rights groups and concern from a range of countries.
This was the message at a small picket held outside the Port Elizabeth City Hall on Tuesday in support of The Great Return March, which is a series of rallies by Palestinian people culminating on Tuesday on the anniversary of the Nakba.
The Tanaiste has expressed Ireland's outrage to Israel after the latest deaths in Gaza. The day before she had expressed her opposition to the United States decision to move the embassy to Jerusalem and stated that London had no plans to do the same.
Russian Federation and China on Tuesday also raised concerns over the deadly violence.
Turkish Prime Minister Binali Yildirım called on Muslim countries to reassess their relations with Israel due to the deaths, Reuters reported.
"The killing of children, women and defenseless people of Palestine and the occupation of Palestinian lands has become the main strategy of the Zionists over the 70 years of occupation", said Iranian foreign ministry spokesman Bahram Ghasemi on the ministry's website.
"Now is the time for all of us to give voice to the yearning among our citizens for new thinking on achieving peaceful resolutions to the conflicts which challenge us all".
At this very unsafe moment in time for the Middle East, I call on all involved to return to meaningful diplomacy, to avoid escalation and show the utmost care and respect for worldwide treaties and agreements.
The Sinn Féin deputy Dáil leader has called for the expulsion of the Israeli Ambassador to Ireland.