The T-4 base lies in Syria's central Homs province and is also known as the Tiyas airport.
A military airbase belonging to the Assad regime near the Syrian city of Homs was hit with missiles overnight Sunday, local media reported.
The SANA news agency earlier reported citing a military source that Syrian air defense systems had shot down eight missiles when repelling the attack.
The TV channel earlier reported that Israeli warplanes were carrying out reconnaissance flights in the border area between Syria and Lebanon when a missile strike against the Syrian military airfield was delivered.
The base is in a strategic desert area, where Syria's main gas fields are located.
The agency said it was likely "an American aggression" but US officials say the United States had not launched airstrikes on Syria.
Those reports could not be independently confirmed by dpa and an Israeli military spokeswoman told dpa she did not want to comment on the Syria raid. It had been under the control of Islamic State militants until the Syrian army and its allies regained control a year ago after heavy Russian military intervention.
Israel carried out strikes against a Syrian government base in the country's centre in February, with the Observatory identifying it at the time as T-4.
Israel has previously said Syria had allowed Iran to set up a complex at the base to supply its ally, the Lebanese militant Shi'ite group Hezbollah, with weapons.
Rescue workers and activists said dozens died over the weekend in a chemical assault amid renewed fire by Assad's government on a rebel stronghold near Damascus.
The Pentagon denied that the USA was responsible for the Monday strikes, which came hours after President Donald Trump vowed there would be a "big price to pay" for the chemical attack.
The US missile strike was against a Syrian air base which Washington said was used to launch the strike.
The missile attack came shortly after US President Donald Trump issued a stark warning over an apparent "chemical" attack in Douma, the last rebel-controlled town in an eastern suburb of Damascus.
At least 42 civilians were killed in the attack, which the United States, Turkey and the European Union said was likely carried out by the government of President Bashar Al-Assad, who is waging an 8-years-long battle to shore up his family's authoritarian rule.