The La Liga side go into Tuesday's game knowing a score draw will be enough to seal their passage past Jose Mourinho's men, but, as they found out in the first leg, finding a way to beat De Gea is easier said than done.
"I am expecting United to go through, mainly because this is the poorest Sevilla side in years".
That billing belongs to the likes of Barcelona, Real Madrid, Bayern Munich and United's local rivals and runaway Premier League leaders Manchester City.
Tonight's tie is evenly poised after United's 0-0 draw in Sevilla three weeks ago, a creditable result but one that leaves Mourinho's side vulnerable to away goals.
"Even if Paul Pogba was fit I don't think he would get in the United team, as he has suffered from the confusion that Alexis Sanchez's arrival has brought to the team".
Manager Jose Mourinho was unsure whether his midfielder would still make the matchday squad against Sevilla at his pre-match press conference on Monday: "He trained a little bit after you left".
The last team to advance in any knockout stage despite a goalless draw at home in the first leg was Atletico Madrid, who defeated Chelsea 3-1 at Stamford Bridge in the semifinals in 2014. I say Liverpool because they are an example of a very good team, a good example of an important stadium with a big tradition. "I don't feel that we have any advantage in this moment".
"It's fine, it's something you've got to accept so that is where I'm at".
That victory meant the Red Devils secured a Champions League spot for only the second time since the retirement of club legend Sir Alex Ferguson, and Mourinho, who had dismissed the Europa League as a competition in the past, admitted how vital that triumph was.
Second in the Premier League with a top-four place all but assured, United will be back in the Champions League next season, but are not yet finished in this year's competition.
"I think when you are in the last 16, it looks really, really far".
"We don't know yet", said Mourinho.