Sporting Gijon stunned Real Madrid's goalkeeper with a second goal from Mikel Vesga in the 50th minute.
After scoring against Gijon, Isco flashed a new goal celebration.
Isco scored a last-minute victor as a weakened Real Madrid came from behind twice to beat Sporting Gijon and remain in control of the La Liga title race.
In the final minute of the game Madrid got their goal, Isco finding a pocket of space on the edge of the area and firing a strike inside Ivan Cuellar's near post.
"It is a relief to be able to score and take the three points, that was what we wanted".
"It is hard, there isn't time to rest, but we are working very well and we're good physically". They don't have many minutes, but that's what makes a team great. When we need everyone, they're there.
Barcelona hosts Real Sociedad on Saturday, its first match since losing at Juventus 3-0 in the Champions League this week. "We didn't control the game like we should have", he added. A report on the situation from the Spanish publication has it that a contract extension for Zidane until 2018 is a "formality" regardless of any silverware in La Liga or the Champions League that Real may or may not win.
Asensio saw his close-range effort chalked out for offside after the ball came back off the crossbar.
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Isco's first goal was a superb solo effort in the 17th to cancel out Duje Cop's opener for Sporting.
Sporting's joy was short-lived as Isco was allowed a touch too much room inside the area, shuffled away from Carlos Carmona, skipped past Vesga and Fernando Amorebieta, and lashed a shot into the top corner for a similarly high-quality equaliser.
Zidane said he wasn't sure if Bale would be ready to play the return leg of the quarterfinal against Bayern next week.
But Alvaro Morata headed Madrid level again in the 59th, and the pacesetters kept pushing until Isco netted the victor.
After the match, Isco said he just wanted to spend less time on the bench. "I don't know why people are surprised when I say I want to play more".
After the match Isco once again told the press that he's happy in Madrid and he wants to stay at the club.
They lead Bayern Munich 2-1 in their Champions League quarter-final ahead of Tuesday night's second leg in Madrid.
Atletico Madrid banked on Yannick Carrasco's double to ease 3-0 past bottom placed Osasuna, but Diego Simeone's side once again showed how bad they have been this season when it comes to scoring penalties. Atletico had two penalties saved, Salvatore Sirigu making two saves in two minutes.