The Brit came off his bike during a reconnaissance of the 26.1 km individual time trial course on stage four in Roanne, and reports in France claim the Brit has suffered a suspected broken pelvis.
Froome - a four-time victor of cycling's biggest event - was taken to hospital after crashing during a reconnaissance ride ahead of stage four of the Criterium du Dauphine. He hit a wall. He was using the Dauphine has his final warm up race for the Tour de France.
Team Ineos released a statement that confirmed the 34-year-old crashed towards the end of his route recon in Auvergne-Rhone-Alpes, sustaining injuries including a fractured right femur, a fractured elbow and fractured ribs.
In five of the last seven years, the victor of the Dauphine has gone on to also take the Tour De France title - with Froome doing so three times himself.
Ineos staff praised the swift response from French medical teams and team doctor Richard Usher said: "I would like to commend the treatment Chris received from emergency services and all at Roanne Hospital for assessing and stabilising him". "It'll take quite a long time before he races again".
"One of our big strengths on this team is coming together in hard moments, and we will ensure we do everything possible to support Chris and his family".
Froome's wife, Michelle, tweeted that she was on her way to join him and ascertain just what injuries he sustained.
He would have been chasing the victory that would have seen him equal the record five Tour de France wins of Jacques Anquetil, Eddie Merckx, Bernard Hinault and Miguel Indurain.
Seeking a fourth win in the key preparation race, Froome was eighth in the Dauphine standings, 24 seconds behind leader Dylan Teuns of Belgium.
Britain's Chris Froome suffered a "very serious" crash during a practice ride before the stage and has been ruled out of the Tour de France in July.