Towns just outside Dayton, Ohio, took some of the heaviest hits.
"I had grabbed a flashlight, I knew we was going to the basement".
This aerial photo shows tornado damage at the Westbrooke Village Apartment complex in Trotwood, Ohio, Tuesday, May 28, 2019.
This latest storm comes after tornadoes and flood waters killed at least six people in Oklahoma over the weekend, including two people in El Reno, near the state capital, on Saturday.
The past couple of weeks have seen unusually high tornado activity in the US, with no immediate end to the pattern in sight.
A series of destructive tornadoes tore through Ohio's Miami Valley Monday night, with some so close together that they crossed paths, according to CBS News No fatalities have been reported and the total number of injuries is undetermined.
Andy Hatzos, a weather forecaster for the National Weather Service in Wilmington, Ohio, tells TIME that the NWS is beginning to process the damage ratings of the tornadoes that passed through Northern Ohio.
Residents and volunteers worked on Tuesday to clean up debris and fix homes in Celina, Ohio, where a tornado touched down and killed an 81-year-old man.
A round of storms Tuesday night and Wednesday morning resulted in several damaging tornadoes in Kansas.
Almost 80 people in and around Dayton went to hospitals with injuries, said Elizabeth Long, a spokeswoman for the Kettering Health Network.
There were no immediate reports of injuries but some homes suffered significant damage. "I just started screaming and my neighbors heard me and said, 'Sue! Sue!"
But the severe weather wasn't limited to the Midwest. The last such stretch was in 1980.
The Ohio Department of Transportation asked drivers to avoid Interstate 75 north of downtown Dayton because of debris scattered on the highway.
Residents in Pendleton, about 56 km northeast of Indianapolis, were being urged to remain in their homes Tuesday morning because of dangers posed by fallen trees, downed power lines and utility poles that were also blocking roads.
The weather service issued a tornado emergency for Kansas City, Missouri and its densely populated western suburbs. Many houses were left with severe damaged and some structures were wiped out altogether, with trees were ripped out by the roots and stern among the damage.
Ohio Gov. Mike DeWine on Tuesday declared a state of emergency for three counties impacted by the severe weather.
Outbreaks of 50 or more tornadoes have happened 63 times in US history, with three instances on record of more than 100 twisters, said Patrick Marsh of the Storm Prediction Center.
OH is accustomed to storms during tornado season, but Monday night's tornado cluster was out of the ordinary because of its strength, he says. But Monday's outbreak was unusual because it happened over a particularly wide geographic area and came amid an especially active stretch of tornadoes, he said.
Two tornadoes categorized as EF3 or stronger also struck late on Monday near Dayton, including one just south of Wright-Patterson Air Force Base, Marsh said. He says up to 40 homes were damaged Monday night, with some houses moved off their foundations by the storms.
Scientists say climate change is responsible for more intense and more frequent extreme weather such as storms, droughts, floods and fires, but without extensive study they can not directly link a single weather event to the changing climate.