J'Neil Bennett had the honour of being the first player to score in the stadium, before Harvey White doubled the lead from the penalty spot.
Now the Spurs manager and his players will be expected to provide the finishing touches to this highly ambitious project.
Premier League stadium building is now an arms race and Tottenham's 62,062-seat mansion is an escalation.
Tottenham legends will play a game against Inter Milan on March 30 in a second and final test event after Spurs' Under-18s side took on Southampton on Sunday.
It has been the prospect of playing at this magnificent new stadium that has helped keep Pochettino at the club amid interest from Real Madrid and, earlier this season, Manchester United.
Should everything follow the revised plan, and the Palace match takes place as scheduled on April 3, Tottenham will play the home leg of their Champions League quarter-final against Manchester City at their new ground rather than at Wembley, which has been a temporary base while the building work has been in progress.
"We're going to have one of the most attractive stadiums in the world, and that's great, but we have to accompany that progression: I think it will be very hard to take a step up without recruiting", the France World Cup victor said in an interview with L'Equipe. I can see the difference between the state of the club when I arrived and today. We all feel the same.
"We need to cry because our dream became true".
Tottenham's new stadium will be the first in England to operate a cashless policy for all purchases on match days.
Mauricio Pochettino's squad went into the global break sitting third in the Premier League table and having progressed to the quarter-finals of the Champions League, where they will face Manchester City.
It is the definition of "modern stadia", with a key feature being the world's first ever retractable pitch whereby one surface can slide out and allow for a different kind of football game to take place in the stadium. Few will say it has not been worth the wait. Thank you so much to the fans for being patient.
"But now all the effort has paid off and it is going to be fantastic".