Esketamine nasal spray approved for management of treatment-resistant depression

Esketamine nasal spray approved for management of treatment-resistant depression

Experts have said that while conventional antidepressants like the SSRIs or Fluoxetine or Paroxetine, Escitalopram etc. reduce depressive symptoms by increasing release of a chemical serotonin in the brain, Esketamine acts differently. That speed "is a huge thing because depressed patients are very disabled and suffer enormously", said Dr. John Mann, a psychiatrist and researcher at Columbia University. Because ketamine can cause hallucinations and out-of-body experiences, the new drug must be administered in a clinical setting.

One short-term trial that lasted four weeks determined that a combination of Spravato and an oral antidepressant demonstrated a "statistically significant effect" compared to a placebo.

Since enrolling in a Spravato trial two years ago, Prothro says her depression has lifted and she's returned to hobbies she abandoned years ago, like gardening.

The FDA's approval of Spravato is only for patients with depression who have failed to find relief with at least two other drugs. "We have carefully reviewed the drug, and it met our criteria to get approved for depression treatments". J&J priced the drug at a wholesale acquisition cost of $590 to $885 per treatment session, depending on which dose patients receive.

The approval of Spravato could potentially open the door for other types of antidepressant approvals in 2019, particularly in postpartum depression. Generic ketamine is approved as an anesthetic, not as an antidepressant. Meanwhile, esketamine delivers results within hours or a few days. "This has implications for treatment-resistant patients who have not responded to standard antidepressants, as esketamine potentially offers a better chance at achieving remission than traditional medications".

A decades-old drug, ketamine is already used off-label to treat depression by some doctors.

Drug addiction specialists and support groups like Nashville's Addiction Campuses are not for or against the new form of treatment.

Patients will inhale the drug under supervision at these centers once or twice a week. Such therapies are generally not covered by insurance because they haven't been approved as safe and effective by FDA regulators.

But he hopes that doctors who are now using ketamine continue to do so.

Controversial: The Food and Drug Administration approved a controversial drug for depression Tuesday that could be the first of a long-awaited wave of new treatments, but has also raised concerns about abuse, The Wall Street Journal reports. The AP is exclusively responsible for all content.



Related Posts

Pro Bowl LB C.J. Mosley to sign huge deal with Jets
Last season, Mosley racked up 105 total tackles, five pass defends, one interception and 0.5 sack in 15 games. Mosley has been named to the Pro Bowl the past three seasons and four of his five seasons in the NFL.

Will EU backstop promises help Theresa May to win her Brexit vote?
British lawmakers are scheduled to vote Tuesday on whether to approve May's Brexit deal, which they resoundingly rejected in January.

Longtime Charger Eric Weddle signs with LA Rams
With a deep free agent market for safeties this offseason, plenty of teams seem to believe Weddle has a bit left in the tank. Talib is second among active players in career interceptions with 35, while Weddle is ninth with 29.

U.S. warns Germany a Huawei deal could hurt intelligence sharing
Also on U.S. advises Italy to steer clear of China's new Silk Road... because it's a National Security issue? The Chinese telecoms behemoth has strenuously denied the espionage allegations.

Windows 10 Can Now Automatically Roll Back Faulty Updates
The company explains that "this is only done when all other automatic recovery attempts have been unsuccessful". We removed some recently installed updates to recover your device from a startup failure .

'Harry Potter: Wizards Unite' is about protecting muggles
You can also cast spells while playing Harry Potter: Wizards Unite , but be mindful that this consumes Spell Energy . New compared to Pokemon Go is the addition of immersive environments, which can be accessed via Portkey .

Chiefs to sign safety Tyrann Mathieu
Conor Orr is writing up grades for every major National Football League free agency signing here. With Morse's departure, the Chiefs will likely turn to Austin Reiter as their starting center.

Miami Dolphins add free agent tight-end Dwayne Allen
Now, Allen will play alongside fellow tight end Nick O'Leary, who the Dolphins signed to an extension in December. Signing Allen is a solid move for the Dolphins, who lack a consistent threat at the tight end position.

'I'll F**k You Up': Russell Westbrook Warns Utah Jazz Fans
Westbrook is not the only player to have trouble with fans in Utah with former Cleveland Cavaliers guard J.R. Paul George made just two (of eight) field goals, but finished with 14 points, 11 rebounds and 4 assists.

Facebook Removes Elizabeth Warren Ads, Then Restores Them After Outcry
Facebook's policies limit the extent to which advertisers can reference Facebook or Instagram in the text or imagery. Almost a dozen other campaign ads addressing her proposal to slam tech companies were not affected.

© 2015 ExpressNewsline. All Rights reserved.