The American claimed a record-breaking four golds - she has now amassed an unprecedented 14 at the worlds - in Doha and added one silver and a bronze.
The sports world looks on Monday evening to Monaco.
Biles became the first woman to win a fourth all-around title at the 2018 World Artistic Gymnastic Championships. He went to on to clinch the 2018 US Open title and 2019 Australian Open, along with returning to world number one ranking.
"I want to give a huge thank you to the Laureus Academy for giving me the Laureus Breakthrough of the Year award".
While accepting his award as the Sportsman of the Year, Djokovic admitted it was his wife Jelena who had helped him back after his darkest moments.
Tennis world No. 1 Novak Djokovic of Serbia won his fourth Laureus World Sportsman of the Year on Monday, and American record-holding gymnast Simone Biles bagged the World Sportswoman of the Year Award thanks to her dominant world championship performance last year.
America's 14-time major victor Woods won the season-ending Tour Championship by two shots to record his first win in five years following spinal fusion surgery.
The night's biggest and most emotional honor was presented to Vonn, who ended her skiing career on February 10 with a bronze medal at the world championships in her final downhill race.
Kenyan marathon runner, Eliud Kipchoge who set the world marathon record in Berlin won the Exceptional Achievement Award while World Cup winners, France won the Team of the Year.
Yuwa, a sport for development organization that works in the rural region of Jharkhand in northern India, received the Laureus Sport for Good Award for their life-changing work in using football to improve the lives of young girls from disadvantaged communities.
Wenger received a guard of honour at the ceremony from legendary Arsenal captain Cesc Fabregas and football legends Alessandro Del Piero, Luis Figo, Fabio Capello, Didier Deschamps, Cafu and Alex Scott.
Regarded as the greatest women's skier of all times not because of her four World Cup titles and three Olympic medals but for the sheer tenacity to comeback after a slew of career-threatening injuries, Vonn broke down on stage while receiving the Laureus Spirit of the Sport award.