Ms Warren announced her campaign in her home state of MA at a mill site where largely immigrant factory workers went on strike about 100 years ago, a fitting forum for the longtime consumer advocate to advance her platform. Ted Kennedy (D-Mass.) - introduced Warren Saturday and revealed his endorsement of Warren.
Trump campaign manager Brad Parscale said in a statement Saturday that Warren has been "exposed as a fraud by the Native Americans she impersonated and disrespected to advance her professional career, and the people of MA she deceived to get elected".
After Lawrence, Warren is set to travel north to campaign in New Hampshire before flying to Iowa for a three-stop tour across the state on Sunday - her second visit to the Hawkeye State since announcing the formation of an exploratory campaign on New Year's Eve.
She said Trump is not the cause of what is broken in America, just the latest symptom.
Speaking in Lawrence, Massachusetts, Ms Warren grounded her 2020 campaign in a populist call to fight economic inequality and build "an America that works for everyone".
"This is the fight of our lives", she said.
I will always vote to reelect Warren to the Senate, but she should not be the Democratic nominee.
The Massachusetts Democrat, a leader of the party's progressive wing, made her announcement on Saturday from an historic site in Lawrence, northwest of Boston, that launched the USA organised labour movement.
"I am in that fight all the way", she told supporters. "Separating a momma from a baby does not make this country safer", Warren said in an interview with CNN last summer, a message she has returned to during her time on the campaign trail.
In order to hold large American corporations accountable, she suggested putting workers in "corporate boardrooms where the real decisions are made", break up monopolies when they "choke off competition", take on Wall Street banks and to prosecute companies that "rob their workers". "And that is why I stand here today: to declare that I am a candidate for President of the United States of America".
President Trump has often taunted Warren, dubbing her "Pocahontas" to mock her heritage claims.
For her 2020 campaign, Warren has proposed a 2% wealth tax on fortunes of $50m or greater and a 3% tax on fortunes $1bn or greater.
Warren has often spoken of how her parents eloped after her father's family disapproved of his future wife's Native American lineage, but Warren for years could never produce documentation to bolster her claims.
Warren faced renewed criticism this week over her controversial Native American heritage claims after the Washington Post reported that she listed her race as "American Indian" on a Texas State Bar registration card in 1986. "I want to see a revival of civic grace".
Warren will not go into her presidential announcement with the wind at her back, however.
The campaign launch comes at a challenging moment for Warren. "That's a fundamental promise of America", she said. To announce the results of the DNA test, Warren used a campaign-style video that tried to directly address questions about her background.