In an interview to The Times of India, the three-time Grand Slam victor Stan Wawrinka commented on the Big Three's dominance.
Should Djokovic, a six-time victor at Melbourne Park, beat an as-yet-unknown qualifier, he could face wild card Jo-Wilfried Tsonga in the next match, with Denis Shapovalov a possible third-round opponent and Kei Nishikori potentially awaiting in the last eight.
The pair have met four times in Australian Open finals, with the Serb winning them all.
Kyle Edmund, back at the scene of his semi-final appearance 12 months ago, was also given a hard opener at the year's first grand slam against former top-10 stalwart Tomas Berdych, who is unseeded following injury.
Second seed Rafa Nadal, who has question marks concerning his fitness after pulling out of the Brisbane International, will play unseeded local James Duckworth in the first round.
Murray, who is coming back from a long-term hip injury, won just two games against world No. 1 Djokovic during the practice match, which finished incomplete at 6-1, 4-1 and was played in front of a sizeable crowd at the Margaret Court Arena.
There will be some doubts hanging over the Serbian after losing finals in London and Paris, as well as in the Doha semi-finals last week to Roberto Bautista Agust, but Wilander believes he is well-placed to win a record-breaking seventh title in Melbourne.
Serena Williams, who is seeded 16th, faces fellow mother Tatjana Maria of Germany in her first competitive match since her tempestuous US Open final loss to Naomi Osaka. Halep has drawn another first-round against Kaia Kanepi, who beat her at the same stage at last year's U.S. Open, and a possible third rounder against unseeded Venus Williams. But being so close, I'll give it a go.
Defending champion Caroline Wozniacki takes on Belgian Alison van Uytvanck in round one and could potentially meet 30th seed Maria Sharapova in the third round.