Jacobs earns the IBF World Middleweight title for his victory.
Jacobs' win capped what's been a flurry of activity in the 160-pound division over the last seven weeks.
Derevyanchenko seemed to get frustrated in rounds eight and nine as Jacobs gained control but a strong 10th suggested it was anything but a shut-out.
Soliman and Johnson are credible opposition on route to a world title match, but Jacobs would likely have inflicted the same damage on the pair of global opposition, much like he has when dispatching Peter Quillin (W TKO 1), Sergio Mora (W TKO 2 & W TKO 7) and Caleb Truax (W TKO 12).
Jacobs (35-2, 29 KO's), 31, of Brooklyn, a four-time New York Golden Gloves champion, boxed beautifully, and landed the harder punches throughout.
Even before Jacobs, whose official purse was $1 million (though he earned closer to $1.6 million because of his HBO deal), won on Saturday, there was ample talk that Jacobs would be Alvarez's opponent in May, as long as Alvarez defeats Rocky Fielding for a secondary super middleweight belt on December 15 at Madison Square Garden in the first fight of his record-breaking DAZN deal.
Tonight will be the last time Jacobs will box under his HBO contract since the HBO sports announced it would no longer cover boxing after over 40 years in the fight game. Ukraine's Derevyanchenko 12-0 (10KO's) has not found many opponents willing and able to last the distance, and in those 12 opponents, the 32-year old has not been fed lightly.
At the end of the 1st round, Jacobs connected with a right hand on the top of Derevyanchenko's head to drop him.
Derevyanchenko Sunday morning could be the fourth current Ukrainian world champion after Vasyl Lomachenko, Alexander Usik and Artem, dalakan. He's expected to return to 160 pounds afterward and Jacobs, who narrowly lost to Golovkin previous year, wants to be the opponent. "I've always felt that I was the best middleweight in the world with this type of fight I'm that much closer to all the that glory and to proving to the world I am the best". "I mean, I know that".
It's a fight Jacobs wants.
"A guy that's inexperienced with only 12 fights, I would presume that it would be a second guess on his behalf". "Seeing his fights and studying him, I knew that if I let him load up and miss the shots, I could come back and hopefully get another knockdown", Jacobs said.
"He worked the body and kind of gassed me, but I know I have another level in me, above him".
"It was a great fight". Jacobs' ring generalship and IQ was a huge factor in the victory.