The gruesome-looking injury occurred when Messi landed hard on his right arm after getting wrapped up with Sevilla midfielder Franco Vazquez. He was examined on the sidelines before he was replaced by Ousmane Dembele.
Messi has been ruled out for three weeks after sustaining a fractured arm in a heavy fall during Saturday's 4-2 La Liga win at home to Sevilla. "He will be out for approximately three weeks", the club said on fcbarcelona.com.
Ernesto Valverde feels Lionel Messi's injury provides an opportunity for Barcelona players to step up, although he acknowledges the team will miss their captain. "We know what he gives us and we know what he does to the opposition. But we have to take it on, we have resources [to come into the team], despite the opposition being tough".
"There's a big difference between having him on the pitch or not but we have a strong enough team to win games whether he plays or not".
"It's clear that we will notice his absence but we will cope and we have resources, even though we will be facing some very hard teams".
Despite Messi' absence, Barca continued to dominate and carve out chances, although they were unable to add to their tally as they went into the break two goals up.
At the time of writing, the severity of Messi's injury remains unknown but considering the pain he was in, it would not be surprising to see him miss some crucial fixtures for the Catalan giants.