Nobel Prize in Medicine awarded to cancer immunotherapy scientists

Share
Nobel Prize in Medicine awarded to cancer immunotherapy scientists

Two researchers from the U.S. and Japan have won the Nobel Prize in medicine for discoveries that have revolutionised cancer care, turning the body's immune system loose to fight tumours in an approach credited with saving an untold number of lives.

The two winners of this year's Nobel Prize in Medicine or Physiology made discoveries that 'constitute a landmark in our fight against cancer, ' according to a statement from the Nobel Assembly of the Karolinska Institute that awarded the prize.

The winners were chosen for "for their discovery of cancer therapy by inhibition of negative immune regulation".

Allison, 70, "realised the potential of releasing the brake and thereby unleashing our immune cells to attack tumours", the Nobel jury said. Subsequent research has extended this approach to new immune regulatory targets, most prominently PD-1 and PD-L1, with drugs approved to treat certain types and stages of melanoma, lung, kidney, bladder, gastric, liver, cervical, colorectal, and head and neck cancers and Hodgkin's lymphoma.

Japanese Prime Minister Shinzo Abe congratulated Dr. Honjo in a phone call, telling him: "I believe the achievements of your research have given cancer patients hope and light". It's been the most successful attempt yet to rid cancer patients of life-threatening tumours and, ultimately, the disease itself.

Yes, the CTLA-4 antibody inhibitor ipilimumab and PD-1 inhibitors pembrolizumab and nivolumab have all been approved as therapies for treating melanoma in combination with cancer vaccines.

"The goal is to neutralise these molecules, among them CTLA-4 and PD-1, and these are what the recipients of the Nobel prize have been working on", said Pierre Goldstein, emeritus professor at the Marseille-Luminy Immunology Centre.

"I'm honored and humbled to receive this prestigious recognition".

This screenshot shows the official Nobel Prize Twitter account. After pondering what career to pursue - diplomat, lawyer or doctor - Honjo entered the Faculty of Medicine at Kyoto University in 1960 and moved on to the graduate course. Before protein inhibitors were invented cancer treatments were restricted to surgery, radiation, and chemotherapy.

In 2012, a pivotal study demonstrated clear results for patients with different types of cancer.

Prof Allison said it was "a great, emotional privilege to meet cancer patients who've been successfully treated with immune checkpoint blockade". By releasing that brake, Honjo's research had found a "strikingly effective" treatment against cancer.

Allison - who received his bachelor's degree in 1969 and his doctorate in 1973 at UT Austin - shares the award with Tasuku Honjo, a professor at Kyoto University.

Therapy developed from Honjo's work led to long-term remission in patients with metastatic cancer that had been considered essentially untreatable, the Nobel Assembly said.

Share

Advertisement

Related Posts

OnePlus 6T official accessories with prices leaked ahead of launch
On the back, we only have a dual-lens camera, compared to the triple-lens shooter on the R17, and the OnePlus logo. Simply putting your name forward is not enough to guarantee you'll be given a OnePlus 6T , for instance.

Microsoft Surface Event October 2nd: Everything we expect
However, a WinFuture report states that the Surface Pro 6 will cost the same as the Surface Pro, which was introduced past year . According to this rumor, Microsoft isn't updating the Surface Laptop 2 and the Surface Pro 6 with USB-C (or Thunderbolt) ports.

Packages with suspected ricin sent to Pentagon, Navy chiefs
Postal Service mail received at the screening facility on Monday is under quarantine and 'poses no threat to Pentagon personnel'. The Houston Fire Department tweeted that a hazardous materials crew is on scene at the evacuated office building.

Google Maps Picks Up Key Commuter Features
Most importantly perhaps, Google is adding Google Play Music , Spotify , and Apple Music integration to Google Maps . All of this will be factored into your ETA, so you won't need to guess at when you might arrive at your destination.

Donald Trumps heralds 'new dawn' with trade deal
The US and Canada have reached a deal to reform the North American Free Trade Agreement (Nafta ) after last minute negotiations. Derek Burleton, deputy chief economist at TD Economics, echoed the sentiment of many in expressing relief at an agreement.

Secret 'Venom' End Credits Scene Hints At What Sequel Will Be About
Late actor Amrish Puri became one of the most loved and popular villains of Indian cinema after portraying the role of Mogambo . In an interview with ComicsExplained , he was asked which was his favourite scene from the movie, and he didn't hold back.

Trump has sharp words for ABC's Vega, CNN's Collins
Similarly to Vega, Collins was reproached with the president wagging his finger at her saying her actions were "not nice". Vega later addressed the exchange on Twitter, saying she believed the President had clearly heard her questions.

Most US cell phones to receive 'Presidential Alert' text on Wednesday
The WEA system is used to warn the public about unsafe weather, missing children, and other critical situations. The test is for the Wireless Emergency Alert system in coordination with the Federal Communications Commission.

Kim Kardashian West ‘embarrassed’ by Kanye West’s pro-Trump rant
You'd get [their two-year-old son] Saint one". "I was like, 'Oh my God, I can't sit here and organise my Instagram with you". She added: 'I'm kind of annoyed because I wish he would understand I'm exhausted, like, go get your own Band-Aid'.

Turnout in Macedonia's name referendum unlikely to reach 50 percent threshold
That figure was based on data from 85 percent of polling stations, according to State Electoral Commission head Oliver Derkoski. Western leaders had poured into Skopje in recent weeks to push for a "yes" vote, in a measure of the stakes of the referendum.

© 2015 ExpressNewsline. All Rights reserved.