"We will never surrender America's sovereignty to an unelected, unaccountable, global bureaucracy", Trump said, in language popular with his political base.
Trump was making his eagerly-awaited president's address at the United Nations when he typically boasted about his administration being the "most accomplished" in America's history.
"We can not allow the world's leading sponsor of terrorism to possess the planet's most unsafe weapons", Trump said, citing Iran's "threatening Israel with annihilation" and chants of "death to America".
Trump saved his harshest rhetoric for the regime in Iran, which he castigated for sowing "chaos, death and destruction" in the Middle East.
Over the summer, Trump had said he would meet with Rouhani without preconditions to negotiate a new deal, an offer reiterated on Sunday by U.S. Secretary of State Mike Pompeo and extended to Iran's supreme leader, Ayatollah Khamenei. "We ask all nations to isolate Iran's regime as long as its aggression continues", Trump said.
"The US will always choose independence and cooperation over global governance, control, and domination", Trump said.
The United States will not tell you how to live or work or worship.
He also touted progress made on border security and denuclearizing the Korean Peninsula.
Rohani said that the Trump administration is determined to make all global forums "ineffectual" and is trying to initiate regime change in Iran, despite its denials of doing so. He received a stay of punishment at least until Thursday, when he is to meet with Trump at the White House. "I think countries that sign this and then show up to this photo op should be very careful - they don't really know what they are signing up to".
"Ultimately, the only long-term solution to the migration crisis is to help people build more hopeful futures in their home countries", Trump said.
With cable news chyrons flashing breathless updates about both Beltway dramas, news of Trump's foreign policy moves from the United Nations, led by a new trade deal with South Korea, struggled to break through and disappointed White House aides.
Much to the dismay of Washington's Western allies, Trump slammed the door in May on a deal that the United States and European powers brokered with Iran back in 2015 that allowed for a lifting of sanctions in exchange for restrictions on Tehran's nuclear program.
Moon told an event in NY on the sidelines of the United Nations meeting that declaring a formal end to the 1950-53 Korean War would encourage North Korea to move further with denuclearization.
In his own speech, Iranian President Hassan Rouhani slammed the economic sanctions laid on his nation by the US.
"If you cross us, our allies, or our partners; if you harm our citizens.there will indeed be hell to pay", Bolton said.
The US leader said his meeting with North Korean leader Kim Jong-un in Singapore in June had led to developments unimaginable only a few months ago.
Crude oil prices shot to a four-year high on Tuesday, catapulted by imminent USA sanctions on Iranian crude exports and the apparent reluctance of OPEC and Russian Federation to raise output to offset the potential hit to global supply. He threatened to limit US aid only to countries that are friendly to the United States.