Clooney was taken to hospital with a possible injury and later discharged from the emergency room with a slight contusion on his knee, state news agency Ansa said. He was thrown 20 feet into the air and his helmet struck the car's windshield, causing it to shatter, according to TMZ, which reported it confirmed those details with Clooney's camp.
The car's driver reportedly assisted Clooney after the accident.
Police said they had no information, and the hospital did not respond to requests for comment.
Clooney told a friend it's "good to be alive" after the road accident.
A photo published on La Nuova Sardegna website shows a black scooter on one side of the road, with a dark blue estate auto facing the other way, at an angle across the central reserve.
The clip shows George slam into a Mercedes before flipping over the handlebars of his bike and being flung into the air. Italian officials report that the MRI was negative and he is not in serious condition and he has already been released.
He's now being looked after by his wife Amal Clooney, whom he married in 2014 and has has one-year-old twins Alexander and Ella with, at their Italian home. Local media that had gathered at the hospital said Clooney left in a van through a side exit. Add George Clooney as an interest to stay up to date on the latest George Clooney news, video, and analysis from ABC News.
The family have temporarily relocated whilst George films new TV series Catch-22, which is an adaption of the 1961 Joseph Heller novel of the same name.
George and Amal Clooney.