The next resignation came the following day from Foreign Secretary Boris Johnson, who informed the prime minister's office that he would be resigning before officially sending his extremely sharp resignation letter, in which he feared the U.K.'s new Brexit plan or "the government's song to sing", would leave the country an European Union colony and would represent the death of the "Brexit dream".
Johnson, who wrote in his resignation letter that the Brexit "dream is dying" and that Britain was headed for the "status of colony" under May's leadership, is seen as a potential challenger.
His dramatic resignation followed those of Davis and his deputy Steve Banker overnight over May's plans to keep Britain economically close to the bloc.
On Monday, minutes after Johnson quit, May defended her Brexit plan to lawmakers in the House of Commons - with Johnson absent from his usual place on the Conservative front bench.
"This is not a betrayal", she responded to one of several eurosceptic Conservative MPs who complained, insisting it was "the right Brexit deal for Britain".
According to the proposals agreed upon by the British government on Friday, the United Kingdom and the European Union ahead of Brexit would maintain "a common rule book for industrial goods and agricultural products", and London would commit to "ongoing harmonization" with European Union rules on goods to ensure frictionless trade at ports and the border with Ireland.
Yesterday, when Johnson was supposed to be hosting a summit on the Western Balkans, Downing Street announced he had also gone.
He flew out to Washington DC to convince Mr Trump that Iran would "go for a bomb" if he deserted the agreement, with his words falling on deaf ears as the U.S. later announced it would be pulling out of the deal.
It comes right before Donald Trump's first visit to Britain as U.S. president on Friday, as well as the North Atlantic Treaty Organisation summit in Brussels tomorrow. They also lack the support in parliament to try to change any deal that is agreed with the EU.
Davis himself expressed regret that Johnson had quit, and said it would be "wrong" for his departure to trigger a major rebellion.
He feels so strongly that he has already written - and openly published - a letter of no confidence in Theresa May and sent it to the 1922 Committee chair, Sir Graham Brady.
A Downing Street spokesman confirmed that if pushed to a confidence vote, May would not resign. Her party is divided into hard-and-soft Brexit factions and she has the impossible task of keeping them on the same page.
The latest chaos for May unfolded within 48 hours of what was supposed to be a breakthrough in uniting a fractious government behind her road map for Brexit.
Brussels has repeatedly warned it will not accept "cherry-picking" of elements of its single market.
Margaret Thatcher initially supported the 1975 referendum on the U.K.'s European Union membership, but a string of firings and resignations of cabinet members (sound familiar?) who favored more integration against her wishes led to her downfall. "But the problems they have created for the people remain".
"I've listened to every possible idea and every possible version of Brexit. If not then who knows".
The senior ministers' resignations follow Mrs May's announcement of an agreement over the United Kingdom government's latest Brexit plan at Chequers.
In his resignation letter, Bradley inverted May's claim to her MPs on Monday night that failing to fall in behind her plan would risk the Conservatives losing a general election to Labour. "It's a good thing that we have proposals on the table".
Davis said his job required "an enthusiastic believer in your approach, and not merely a reluctant conscript". The challenge is all very well for people to say I wouldn't do this.
Davis was replaced as Brexit secretary by fellow leaver Dominic Raab.