"This afternoon, the Prime Minister accepted the resignation of Boris Johnson as Foreign Secretary".
Later, it was announced that Brexit campaigner Dominic Raab had been tapped to replace Davis.
After a day when the foreign secretary cancelled meetings for crisis talks at his official residence in central London, Johnson made a decision to walk from his job - just hours after May's Brexit minister David Davis did the same in protest at her plans.
Former Conservative MP Stewart Jackson campaigned for Leave in the 2016 referendum. "An agreement was reached by the cabinet on Friday and now we are moving forward to negotiate that plan", the spokesman told reporters.
It was followed in the early hours of Monday morning by the resignation of Steve Baker, a junior minister in the government, who also worked in the Department for Exiting the European Union under Davis.
Born to a single mother and brought up on a public housing estate in London, Davis pursued a career at sugar giant Tate & Lyle.
Former Prime Minister Tony Blair has repeatedly called for reversing Brexit, echoing other critics such as French President Emmanuel Macron and billionaire investor George Soros, who have suggested that Britain could still change its mind.
"A wider rebellion, a leadership challenge, early elections and possibly another major shift in the Brexit strategy (either way) can not be ruled out", Citi said in a note to clients.
The former Brexit Secretary added that the "current trend of policy and tactics" was making it look "less and less likely" that Brexit would deliver on the referendum result and the Tory commitments to leave the European Union customs and single markets. There will be pressure on the Government not to make any further concession. Environment Secretary Michael Gove said Sunday that it did not contain everything he wanted but "I'm a realist".
But Davis had expressed his unease over a compromise plan right up until the eve of the meeting, writing a letter to May describing her proposal to ease trade and give Britain more freedom to set tariffs as "unworkable".
His resignation comes days after Theresa May secured the cabinet's backing for her Brexit plan despite claims from Brexiteers that it was too "soft". They have criticised the Chequers deal as offering a soft Brexit that betrays what they believe was a mandate for a clean break with the EU.
He told the BBC a contest would take three months and "we physically do not have the time for that" given the United Kingdom is due to leave the European Union next March and both sides want a Brexit deal by October.
May is due to meet her lawmakers later on Monday.