Virus Infections in Early Life Could Set the Stage For Alzheimer’s

Share
Virus Infections in Early Life Could Set the Stage For Alzheimer’s

As they explain in their paper neurological magazine "Neuron", they studied the brains of almost 1,000 people dead and found increased presence -up doubled two herpesviruses (of HHV-6A and HHV-7) in people with Alzheimer's neuropathology, compared to those without had Alzheimer's when they died. The research team created computer models that mapped the genes that were disrupted or activated during the progression of Alzheimer's. Readhead said the connection between finding the virus in the blood and it activating the Alzheimer's genes and triggering the disease is still not understood well.

A new study from the Icahn School of Medicine at Mount Sinai, published in the journal Neuron, has reignited a controversial theory about what causes the neurodegenerative disease by studying the brains of people from three different brain banks. The viruses remain dormant however within the body. Scientists, however, state that it cannot yet be said with certainty that, in fact, herpes can cause or exacerbate the now incurable neurodegenerative disease.

They examined the influence of each virus on specific genes and proteins in brain cells, and identified associations between specific viruses and amyloid plaques, neurofibrillary tangles, and clinical dementia severity.

Alzheimer's disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out simple tasks. "I think they're like gas on the flames of some pathology that may be immune-driven".

Readhead says around 90 percent of children in the USA and the United Kingdom are exposed to these viruses in the first few years of life.The findings don't prove the viruses cause Alzheimer's, nor do they suggest it's contagious.

Leah Rosenbaum at ScienceNews reports that there is more recent support for this theory. As with any complex set of findings, they will need to be confirmed in additional patient cohorts, and further studies to specifically address a causal role for viruses are now being conducted by the research team.

According to one of the study's senior authors, Sam Gandy, although viral and genetic causes are often seen separately, it is possible that the viral protein acts as transcription factors that turn on the Alzheimer's disease genes.

This study has been enabled by the extensive molecular profiling of several large patient cohorts, generated in the course of the National Institute on Aging (NIA) Accelerating Medicines Partnership-Alzheimer's Disease (AMP-AD). Researchers have been down this road before.

More than a century after Alzheimer's discovery, there is still no effective prevention or cure for the disease, not even clear justification.

Alzheimer's remains a mystery, but researchers are confident the new study opens up avenues for finding the cause. That's unlikely to be the end of the story.

Doctors don't know what causes Alzheimer's disease or the best way to treat it, but they have new evidence to suggest that a common virus may play a role in who develops the condition.

Share

Advertisement

Related Posts

5 suspects in custody in connection to teen's slaying at bodega
The group fled the scene and Guzman-Feliz ran to the hospital, where he was later pronounced dead, police said. Anyone with information is asked to call police or to call Crime Stoppers at 800-577-TIPS.

Why Red Hen Owner Refused to Serve Sarah Huckabee Sanders
Wilkinson said she told Sanders: "I explained that the restaurant has certain standards that I feel it has to uphold, such as honesty, and compassion, and cooperation".

Bourbon Barrels Come Crashing Down As Kentucky Storage Facility Collapses
Barton 1792 Distillery is owned by Sazerac, which is based in New Orleans and also owns Buffalo Trace Distillery in Frankfort. A local dispatcher responding on the scene said the air smelled of bourbon, though that's not atypical for an aging facility.

Michael Cohen’s photo with Tom Arnold fuels Trump tape speculation
Since December 2016, Arnold has mentioned the Trump tapes repeatedly in interviews - and for a time was saying that he had them. News asked Michael Cohen about the tweeted photo and he referred their inquiries to Tom Arnold who later contacted NBC News .

Tens of thousands anti-Brexit protesters march in London, demand new vote
Smaller parties, including the Greens and the centrist Liberal Democrats, support having a new Brexit vote. Campaigners against Brexit want another referendum, which they call a "people's vote", to bail on leaving.

Police officer fired after traffic stop with daughter's boyfriend
Kovachs was apparently looking for his daughter, Katlyn Kovach , who he didn't realize was in the backseat of Coleman's vehicle . He threatens her with jail for being "disorderly" and then later says, "You're obstructing me, this is your last warning".

India have strong chance of success in England, says captain Virat Kohli
He added: "Our focus will be on winning the match, it won't be about what me or any one player does on the tour". I have had the good practice. "I went through the fitness test as well so the body is feeling fine".

Italy and Germany clash as migration cuts to the core…
But German Chancellor Angela Merkel has conceded "no solution will be reached" on the overall migration issue at either summit. East EU states like Poland and Hungary refuse to host any of these people to alleviate the burden on their most affected peers.

'YES WE KAN' - Nwankwo Kanu confident Nigeria can shock Argentina
Giusti said: "The players will decide the team, that's a fact". Lionel Messi attends a training session. We played against them without Messi.

Jacket worn by First Lady Melania Trump creates firestorm of controversy
She visited Thursday morning at McAllen, Texas, where she thanked doctors and medical staff for their work at the border. Wilson said the balloons were to show the children that the American people care about them. "Every day is like this".

© 2015 ExpressNewsline. All Rights reserved.