Kerr broke Clarke's 20-year-old record as the White Ferns scored 440-3 in Dublin on Wednesday (Thursday NZ Time) before dismissing Ireland for less than 150 to secure a 305-run win.
The earlier record of 229 not out in the name former Australian captain Belinda was set when Amelia was not even born. Kerr's unbeaten innings makes her only the second woman to score a double hundred in ODI cricket.
Kerr, whose highest ODI score before this series had been 30, signed for Kia Super League side Southern Vipers in May.
Kerr's innings is third highest in ODI cricket, behind Rohit Sharma's 264 and Martin Guptill's 237.
Kerr then completed a remarkable double with a five-wicket bag with figures of 5-17 from seven overs to help the White Ferns complete a three-ODI series sweep of Ireland.
Kerr and Leigh Kasperek, who scored 113, combined for the second largest partnership of all time in women´s cricket of 295 runs for the second wicket.
Kasperek posted a career-best 113, including 10 fours, from 105 balls to eclipse her previous best of 21 not out against India in June, 2015.
Kerr became the second woman to score a ODI double century while also becoming the youngest cricketer ever to score an worldwide double century, breaking a record held by Pakistan men's great Javed Miandad. But that too was brought to a close by the midway stage, when Kerr cleaned her up to pick the first of her five wickets.
"New Zealand, who posted a world record for men and women when they scored 490 for four in the first one-day worldwide, now head to England for a triangular Twenty20 series with the hosts and South Africa".