This time, the Trump administration has said it was prepared to continue strikes until the regime stops its alleged use of chemical weapons.
As fears of a Russia confrontation with Western powers mount, French President Emmanuel Macron expressed his "deep concerns" over the situation in Syria in a phone call with Russian President Vladimir Putin.
Western powers continued to weigh their options on Friday over possible strikes against Syria's regime as pressure built to avoid an escalation following a warning from Russian Federation that military action could lead to "war".
The U.S., France and the United Kingdom launched military strikes Friday night on what the Pentagon said were three Syrian chlorine and sarin gas research facilities in response to a suspected chemical attack by Syrian leader Bashar al-Assad.
But the vote at the end of an emergency meeting called by Russian Federation also demonstrated again the paralysis of the UN's most powerful body in dealing with Syria's seven-year conflict.
Russian Federation also calls it "fabricated".
"Even non-significant incidents would lead to new waves of migrants to Europe and to other consequences, which neither we nor our European neighbours need", Lavrov said.
The US, UK, and France said they launched airstrikes against Syrian chemical sites after obtaining evidence that a chemical weapon was used by President Bashar Assad's government.
The call for action came after a suspected chemical attack on the rebel-held town of Douma in the Eastern Ghouta last week killed over 70 people.
Since 2015 France has carried out air strikes against Islamic State in Syria as part of allied forces linked to the US -led coalition, conducting about 5 percent of total coalition air missions.
"I hope hot heads will cool down and that will be it", he told reporters.
Russian Federation and Syria also clashed with the three Western allies over the legality of the airstrikes and responsibility for the Security Council's paralysis.
Wednesday: Russia's Foreign Minister Sergei Lavrov said Russian military inspectors found no evidence of a chemical attack. "We can not take such risks", he said at a forum. The Kremlin readout said that Putin warned against rushing to blame the Syrian government before conducting a "thorough and objective probe". And the three allies are considering a joint military strike in retaliation.
"Why didn't you wait for the outcome of the investigation you called for?"
On the ground in Syria, rebels in Eastern Ghouta surrendered their heavy weapons and their leader left the enclave, signalling the end of one of the bloodiest assaults of the seven-year war and a major win for the Assad regime.
Trump himself appeared on Thursday to cast doubt on at least the timing of any USA -led military action, tweeting: "Never said when an attack on Syria would take place". Many waved Syrian, Russian and Iranian flags.