He contacted the ambassadors of the five permanent members of the SC to reiterate deep concern about the risks of the impasse and stressed the need to avoid the situation from spiraling out of control.
Guterres expressed regret on Wednesday that the UN Security Council had been unable to reach agreement on the issue of chemical weapons in Syria.
"Today, I called the Ambassadors of the five Permanent Members of the Security Council to reiterate my deep concern about the risks of the current impasse and stressed the need to avoid the situation spiralling out of control", the United Nations chief said.
The Secretary-General's call comes after UN Special Envoy for Syria, Staffan de Mistura, told the Security Council late Monday that at least 49 people had been killed, and hundreds were injured in an alleged chemical attack in Douma on Saturday evening.
"Let us not forget that, ultimately, our efforts must be about ending the bad suffering of the Syrian people", he said.
US President was poised Tuesday to decide on possible military action against the Syrian regime, after vowing to respond "forcefully" to the latest alleged chemical atrocity in the country's civil war despite strong warnings from Damascus-ally Russian Federation.
President Donald Trump should steer clear of any military action involving Syria and avoid a nuclear attack at all costs, former president Jimmy Carter has said. Russian Federation says the number of casualties is not true.
The Secretary General on Tuesday called for worldwide investigators to have unfettered access after an alleged chemical attack in.
The US has so far failed to offer any evidence to support its claims against Syria.