An Aer Lingus flight from Heathrow Airport to Dublin, at 5.45pm on Saturday, has also been cancelled due to the forecast.
However, Dublin Airport has reassured rugby fans that today's flight cancellations "won't affect" their plans to travel to Twickenham.
Some fans travelling to the United Kingdom may have their weekend plans dashed, as according to Evening Standard, multiple flights to and from London have been cancelled due to the snow and ice setting in the UK.
The Ireland-England game kicks off at 2.45pm, with the Irish players searching for their third ever Grand Slam after sealing victory in the Six Nations championship last weekend.
Lufthansa, TAP Air Portugal and KLM were among the other airlines with Heathrow flights cancelled.
Six flights in and out of Dublin and four in and out of Cork Airport have been affected.
Snow and icy conditions has meant several flights, due to arrive and depart from Edinburgh Airport, are the first victims of the latest round of wintry conditions.
AMBER snow alerts have been issued in parts of the United Kingdom as the "Beast from the East 2" hits and some flights have already been cancelled or delayed.
"While this weekend's weather may result in minor delays and some airlines consolidating flights, significant disruption at Heathrow is not now expected", they told The Evening Standard.
The UK Met Office has predicted further bad weather this weekend and has issued an amber weather warning with snowfall forecast on Saturday and Sunday across many parts of England and Scotland.
'We are working closely with our on-site Met Office to monitor the further snowfall expected throughout the weekend. "As always, we advise passengers to check their flight status with their airline before coming to the airport".
This evening, showers will turn to snow in on lower levels as well.
Separately, a Status Orange snow and ice warning for the east and southeast was issued by Met Éireann for this Sunday.