Regeneron And Sanofi Say Test Shows Praluent Lowers Risk Of Death

Share
Regeneron And Sanofi Say Test Shows Praluent Lowers Risk Of Death

"I think that will impress the field and people who have to make (reimbursement) decisions", said Dr. Phillippe Steg, the study's co-chairman who presented the data at the American College of Cardiology meeting in Orlando, Florida.

The drug, Praluent, also led to fewer deaths among high-risk patients, which could be the strongest argument for insurers to finally remove barriers that have severely constrained sales and frustrated physicians trying to get the medicine to patients.

The companies will be providing high-risk patients with a reduced net price for Praluent, in alignment with a new value assessment approach developed by the US Institute for Clinical and Economic Review.

"Not all patients with heart disease are the same".

The trial succeeded on its primary goal - reducing the combined risk of heart attack, stroke, heart disease-related death and chest pain requiring hospitalization - by 15 percent.

"We believe a new paradigm is needed in how all members of the healthcare community collaborate to ensure that patients are able to affordably access the medical treatments they need", said Regeneron chief executive Leonard Schleifer in a statement. "With almost 90 percent of the patients in this trial on high-intensity statins, the data demonstrate that a precision-medicine approach in the field of cardiovascular disease may further advance how we better treat high-risk patients".

Alirocumab inhibits the binding of proprotein convertase subtilisin/kexin type 9 (PCSK9) to the LDL receptor and thus heightens the number of available LDL receptors on the surface of liver cells.

The trial was created to maintain patients' LDL-C levels between 25-50 mg/dL, using two different doses of Praluent (75 mg and 150 mg).

With an LDL target range of 25-50, rather than taking it as low as possible, three-quarters of patients ended up on a lower dose of Praluent and some were taken off the drug if their LDL remained at 15 or lower.

"This trial was consistent with earlier statin trials, showing the greatest benefit in patients with higher cholesterol levels at baseline", said George D. Yancopoulos, M.D., Ph.D., President and Chief Scientific Officer, Regeneron. There was no difference in neurocognitive events or new-onset diabetes.

ODYSSEY OUTCOMES assessed the effect of Praluent on the occurrence of MACE in patients who had experienced an ACS between 1-12 months (median 2.6 months) before enrolling in the trial, and who were already on maximally-tolerated statins.

"Too many patients in urgent need of additional treatment options on top of statins have faced tremendous hurdles to gain access to this important medicine".

ICER's latest analysis sets a value-based price range of $4,500-8,000 per year, net of rebates and discounts, for this group, and the companies have said they will offer discounts of up to 69% to health insurers that reduce prescribing obstacles and will be meeting with USA health plans to discuss pricing adjustments.

The companies followed the data with an announcement to cut the price of Praluent (alirocumab) for the high-risk patients who need it the most - a one-two combination aimed at knocking down Amgen and its rival, Repatha (evolocumab). "This is the right thing to do for patients".

Share

Advertisement

Related Posts

WWE Fastlane: Asuka challenges Charlotte Flair for blockbuster WrestleMania match
Following her victory, Flair was confronted by the victor of the first Women's "Royal Rumble", Asuka. The Queen beat Ruby Riott with the Natural Selection despite interference by the Riott Squad.

Retail inflation soften, industrial production grows
In Nirmal Bang's views, " IIP is likely to come in at 6.7% YoY for January 2018, slightly lower than 7.1% in the previous month. Meanwhile, the Consumer Price Index inflation for February fell to 4.44% for February 2018 compared to the same month in 2017.

Sarb to hold briefing on VBS Mutual Bank
According to Governor Kganyago, this has subsequently increased to 21 municipalities and deposits in excess of R1.5 billion. It is never the intention of Treasury for any bank to be liquidated, particularly a small black-owned bank.

DeMarco Murray, Jonathan Stewart reportedly meeting with Detroit Lions Monday
It didn't take long for recently-released Titans running back DeMarco Murray to find suitors in the free agent market. Of course, both those totals would have ranked tops on the Lions past year , as well as Murray's six touchdowns.

Planet Alpha is an Upcoming Sci-Fi Platformer From Former IO Dev
Debbie Bestwick, Team17's CEO adds: "At their best video games can take us to different worlds on incredible journeys". The game will be released on the Switch, Xbox One , PlayStation 4 and PC in 2018.

US May Offer Mexico, Canada Temporary Metal Tariff Exemptions
Trump is expected to sign a proclamation this week outlining his plan to impose the tariffs, which have angered close US allies. Lighthizer was expected to be in Brussels this weekend for meetings with European and Japanese trade officials.

Xiaomi Mi 7 takes the Geekbench test, matches other Snapdragon 845 phones
The Mi MIX 2S launch is set for March 27 after which the Chinese giant is likely to bring the listed smartphone to reality. And it was reported that the delay of Mi 7's launch is due to the dedicated hardware for the facial recognition feature.

Deadly explosion in Austin kills teen, injures woman
Authorities have not yet said if the blast Monday was related to another explosion on March 2 that left a man dead . They cleared media and others away from the area and are using CapMetro buses to evacuate those in the area.

Omerta: First poster of Hansal Mehta's thriller starring Rajkummar Rao is out!
Rajkummar Rao , the man who was in fine form previous year , will arrive with his first release of 2018 in Omerta . After Shahid , Citylights and Aligarh , actor Rajkummar Rao has collaborated with Hansal Mehta for Omerta .

Virgil van Dijk ready for "massive" showdown with Manchester United
Liverpool FC made Van Dijk the most expensive defender in the world following his January move to bolster Klopp's defence. The Portuguese added: "I think it was a complete performance by us with two different halves, so I think we deserve.

© 2015 ExpressNewsline. All Rights reserved.