City, still in the hunt for four trophies this term, could also become the first team to win a top-flight match at Chelsea, Liverpool and Manchester United in the same season since Wimbledon in 1986-87.
When you take into account that Liverpool defeated Manchester City at Anfield just over 12 months ago and City have not won at this ground for 15 years, can you really make Guardiola's men favourites for this game, despite their results?
Guardiola's side are still unbeaten after 22 league games this season with 20 wins and two draws.
Back in September, the Reds were ripped apart by the Citizens 5-0 at the Etihad Stadium but at Anfield, Klopp's men will hold stronger cards so it will be an intriguing battle. "The records are there to be broken".
"This season at Stamford Bridge we were able to do that, but we still have to go to Anfield and [play away] against Arsenal and Tottenham. It's a big game for us and we are going to plan as much as possible", Guardiola said in his press conference on Friday.
"Normally when this kind of situation [booing] happens it is because he was important for Liverpool fans", the City boss added.
"You can see yourself that the atmosphere at every home game is wonderful".
Mo has been Liverpool's top scorer this season having scored 23 goals in 29 appearances for the Reds since joining them last summer. "With Van Dijk they are even better".
The 24-year-old is now level with former Liverpool and England midfielder Gerrard with six player of the month awards, the most for any player in the competition's history.
"Gabriel was in Barcelona yesterday with Dr Cugat".
I've gone back and forth on this game, taking a different look and approach to it two or three tiimes.
Arsenal's 49 games in 2003-2004 is now top, followed by Nottingham Forest's 42 in 1977-1978, Chelsea with 40 in 2004-2005, Leeds's 34 in 1968-1969 and Liverpool's 31 in 1987-1988. "If I was my players I wouldn't want my manager talking about other things".