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City - who have recorded 19 wins and draw in their last 20 Premier League games - will of course put their incredible unbeaten run on the line, but their opponents have not lost any of their last 13 home games in this competition and have not lost to City at Anfield since 2003.
Guardiola, who is again set to be without captain Vincent Kompany due to a calf injury, believes the weekend clash will provide another stern examination of his team's big-game pedigree, having seen them pass such tests with flying colours at Stamford Bridge, Old Trafford and Napoli's Stadio San Paolo this term.
Liverpool replied through Ronnie Whelan but Kevin Reeves then capitalised on a mistake from Reds goalkeeper Bruce Grobbelaar to make the game safe.
On the match itself, Klopp said: "It's interesting to play against City".
However, Anfield and the atmosphere there should give the Liverpool players that extra push that they need to win this game.
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Counterintuitively, though, only Harry Kane has more goals in the Premier League this season than the pair. They didn't just aim to frustrate.
"We are facing them in their best moment".
Klopp might note that the one side to hold an 11-man City in the league, Crystal Palace, did so using the 4-3-3. "When you look at their results, their form, the team they have got and the belief in the camp, it has got to be their best opportunity". United threatened to have similar joy if they could have shuttled the ball over to Anthony Martial so he could attack Fabian Delph. Manchester City would pay +120 on a road win and +260 if this game plays out to a draw. The pair were instrumental in Leicester's 2015-16 title triumph alongside Jamie Vardy and Riyad Mahrez but have both since decamped to Stamford Bridge, where Kante became a title victor again last season. Others have retreated immediately and sat deep, though none as far as Newcastle with their blanket defence.
Arsenal manager Arsene Wenger has been under intense pressure, but there could finally be some good news for the Frenchman as The Gunners have reportedly taken a significant step forward in signing West Brom and former Manchester United star Jonny Evans. Technical attacking midfielders, particularly slower ones, tend to be omitted by managers who expect to operate without the ball. He can not play for Barcelona in the Champions League as he is ineligible, but two - even one - medal would be welcome because they would be the first club honors the Brazil midfielder, 25, has won.
Containing the in-form winger is likely to be Fabian Delph, who has enjoyed something of a renaissance under Guardiola this season.