AstraZeneca Receives FDA Approval for Breast Cancer Treatment

Share
AstraZeneca Receives FDA Approval for Breast Cancer Treatment

Today, the FDA approved olaparib tablets (Lynparza) for the treatment of patients with metastatic breast cancer whose tumors have a germline genetic mutation, according to a press release. This was true at 2, 5 and 10 years following diagnosis. Most importantly, they uncovered that there was no difference in overall survival two, five, or ten years after diagnosis for women with and without a BRCA mutation.

'Women diagnosed with early breast cancer who carry a BRCA mutation are often offered double mastectomies soon after their diagnosis or chemotherapy treatment, however, our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment.

"No other study has followed a group of patients from diagnosis over a long period of time to discover if carrying a high-risk inherited BRCA gene alters the likelihood of being cured of breast cancer", said lead researcher Professor Diana Eccles from the University of Southampton.

A study has found, however, that it has no effect on survival rates among young women.

Clovis' PARP inhibitor Rubraca (rucaparib) was approved in the U.S.in late 2016 for advanced ovarian cancer patients who have received at least two prior lines of chemo and whose tumors harbor the BRCA mutation.

A study of 1.8 million women demonstrated an increased risk of breast cancer with hormonal contraceptive use - including combined oral contraception (COC), progestin-only pills (POPs), and intrauterine systems - with a dose-response relationship. After 10 years, faulty gene carrier survival was 73.4% compared with 70.1% for non-carriers.

Angelina Jolie made headlines when she underwent preventative surgery after learning she had an up to 87% chance of developing breast cancer.

PALB2 - Works similarly to the BRCA genes.

Mutations in these genes stop DNA repairing itself and increase the risk of cancer developing.

The team tracked the women's medical records for an average period of just over eight years, and found that 651 of 678 total deaths were due to breast cancer. It means that they can take time to discuss whether radical breast surgery is the right choice for them as part of a longer-term risk-reducing strategy.

The study included 2733 women from 127 hospitals in the United Kingdom who had been diagnosed with breast cancer at the age of 40 or below.

'This study can reassure young women with breast cancer ... that breast conservation with radiotherapy is a safe option in the first decade after diagnosis and double mastectomy is not essential or mandatory at initial treatment.

'Decisions about timing of additional surgery to reduce future cancer risks should take into account patient prognosis after their first cancer, and their personal preferences'.

The researchers say that in the future this information could help women and their doctors make informed choices about treatment.

Share

Advertisement

Related Posts

Mixed Reviews for California's Proposed Budget
Of the 2.5 million students that the college aims to serve, about 80 percent are working adults and 49 percent are Hispanic. The plan is to use $100 million over seven years to create the college and fund it annually at $20 million.

Scaramucci likens his crude comment about Steve Bannon to Trump's disavowal
You need to get the team working right and create some level of functionality among the teammates. Bush a few years ago, ' Scaramucci said.

Now is the time to test your home for radon gas
If you are looking to test your home for radon, you can check out Safety Siren Radon Gas Detectors at the Longmont Public Library. Because radon has no taste, smell or color, a home must be tested to find out how much radon is in the air.

Saudi aircraft crash: Fighter jet 'shot down by rebels' in Yemen
But Saudi state news agency SPA reported the fighter jet had suffered a "technical fault" while conducting military operations. Just this week, Houthi rebels announced they've built a new locally designed missile to fight against the Saudi-led alliance.

LSU RB Derrius Guice, Likely Early-Round Pick, Declares for NFL Draft
Guice set the single-season school record for rushing yards in a 285-yard effort against Texas A&M in the 2016 season finale. LSU running back Derrius Guice said Wednesday that he is leaving the school to enter the NFL Draft .

Packers announce coaching changes on defense
The organization is searching for a general manager while Ted Thompson transitions to a senior adviser role in the front office. He hired McCarthy as head coach the following year, and the Packers won six NFC North titles under his watch.

Tuukka Rask Named NHL's First Star For December
Marchand and Schaller scored a little less than six minutes apart in the third to put the game away for the Bruins. Rask struggled to begin the season, but he's been the league's top netminder since the start of December.

Intel taught 250 drones to fly together and it was breathtaking
The record has since been broken by the Chinese drone company Ehang with 1,000 drones during the Chinese Lantern Festival in 2017. These drones have the ability to create up to 4 billion color combinations and create dazzling visual effects.

Courtney Act just flashed the entire Celebrity Big Brother live audience
The camera then quickly panned to Emma, who noted that Courtney was the first star this year to suffer a wardrobe malfunction. Drag queen Courtney Act was confirmed to enter the Celebrity Big Brother house on Friday evening.

Hoda Kotb says she's 'not making Matt Lauer money'
Furthermore, after his firing, NBC continued to receive complaints against the anchor for sexual misconduct and sexual harassment. Still, Kotb, who officially scored the hosting gig alongside Guthrie on Tuesday, said she isn't paying any mind to money matters.

© 2015 ExpressNewsline. All Rights reserved.