Half of new cancer drugs not showing survival gains

Half of new cancer drugs not showing survival gains

At a minimum of 3.3 years after market entry, the study published by them in British Medical Journal (BMJ) reveals, there was still no conclusive evidence that 33 of these 39 cancer drugs either extended or improved quality of life. Of these, eight indications (12%) were approved on the basis of a single-arm study.

An analysis of five years' worth of new approved cancer drugs has cast considerable doubt on their effectiveness and ability to improve a patient's quality of life.

Given the toxicity and expense of cancer drugs, patients should be exposed only "when they can reasonably expect an improvement in survival or quality of life", said Prasad.

Of 23 indications whose survival benefit could be scored with the ESMO-MCBS tool, the benefit was judged to be clinically meaningful in less than half (48%).

"While the European Medicines Agency (EMA) decides which new drugs are safe to be sold in Europe, it's national bodies like Nice (National Institute for Health and Care Excellence) that decide which drugs should be made available to patients".

"The fact that so numerous new drugs on the market lack good evidence that they improve patient outcomes puts governments in a hard position when it comes to deciding which treatments to fund", she writes.

"When there were survival gains over existing treatment options or placebo, they were often marginal".

"The fact that so numerous new drugs on the market lack good evidence that they improve patient outcomes puts governments in a hard position when it comes to deciding which treatments to fund", she said.

He said most cancer drugs - which cost about $100,000 per year of treatment - are being approved based on "flimsy or untested" initial measures and declared that the regulatory system was "broken".

This situation has negative implications for patients and public health - they concluded.

When the cancer in United Kingdom was presented in numbers it was found that 10000 number of lives which could be saved with earlier diagnosis, 352197 number of people diagnosed with cancer each year (2013), 161823 are the annual deaths from cancer (2012), 50% chance of living at least 10 years after cancer diagnosis as of 2010-2011. "But regulatory sanctioning of a comparator that lacks robust evidence of efficacy, means the cycle of weak evidence and uncertainty continues".

"We were quite surprised about the high proportion of drugs entering the market without evidence", said Huseyin Naci, of the London School of Economics and Political Science, one of the study's authors.

But she said that even though many new drugs may only extend patients' lives a few weeks or months, such gains can be worthwhile. Companies often create a lot of hype around their proclaimed benefits.

The research "paint (s) a sobering picture", wrote Vinay Prasad, an assistant professor of medicine at the Oregon Health and Science University, in an accompanying editorial.



Related Posts

Intercontinental Exchange Inc. (ICE) Shares Bought by Dimensional Fund Advisors LP
Prudential PLC owned approximately 0.25% of Intercontinental Exchange worth $97,647,000 at the end of the most recent quarter. The value of the investment in (ICE) went from $653,692,000 to $668,888,000 a change of $15,196,000 for the reporting period.

Year-old girl 'raped' inside toilet of Delhi school
A case of rape has been registered under several sections of Protection of Children from Sexual Offences Act (POCSO). The incident reportedly took place inside the school toilet where the girl was assaulted by housekeeping staff.

Massa questions Kubica/di Resta shoot-out test
Williams are now one of only four teams yet to confirm their line-up for next season. I think maybe I can do another year but I don't decide, the team decides.

Evaluating Insider Trading And Ownership For Carnival Corporation (CCL)
The Company's North America segment includes Carnival Cruise Line, Holland America Line, Princess Cruises (Princess) and Seabourn. TRADEMARK VIOLATION NOTICE: This piece was originally reported by Equities Focus and is the sole property of of Equities Focus.

Moses Finally Hit Uyo For Showdown Against Zambia
You can also follow all the action from Uyo right here on AS English , with our inimitable live coverage. Find out what time Nigeria v Zambia gets underway where you are in the world.

McDonald's employee caught selling cocaine while on shift
Prosecutors say $5,300 in cash was also found inside a dresser in the room of a 2-year-old child. Another time, he sold $6,250 in cocaine to an undercover officer in the McDonald's restroom.

Are Hedge Funds Betting Against Applied Optoelectronics, Inc. (AAOI)?
BidaskClub raised Applied Optoelectronics from a "hold" rating to a "buy" rating in a research note on Wednesday, July 12th. In the most updated research from a number of analysts on Wall Street, the company gets 7 Buys and 2 Sell among 9 analysts.

Snyder: Lower flags to half-staff after Las Vegas shooting
Joined by first lady Melania Trump, the president met with medical personnel, first responders, and family members of the victims. A throng of doctors, nurses and other hospital staff pressed themselves against a thick set of double doors, awaiting Trump.

USA private sector adds 135000 jobs in September: ADP
On the flip side, jobs fell in the trade/transportation/utilities and information sectors, down by 18,000 and 11,000 respectively. Wednesday's ADP employment report threw up the same number of questions as it solved around USA jobs numbers in September.

Microsoft's (MSFT) "Neutral" Rating Reiterated at Atlantic Securities
After $0.34 actual EPS reported by Ares Capital Corporation for the previous quarter, Wall Street now forecasts 2.94% EPS growth. Tocqueville Asset Management Lp bought 1.67 million shares as the company's stock declined 11.27% while stock markets rallied.

© 2015 ExpressNewsline. All Rights reserved.