Half of new cancer drugs not showing survival gains

Share
Half of new cancer drugs not showing survival gains

At a minimum of 3.3 years after market entry, the study published by them in British Medical Journal (BMJ) reveals, there was still no conclusive evidence that 33 of these 39 cancer drugs either extended or improved quality of life. Of these, eight indications (12%) were approved on the basis of a single-arm study.

An analysis of five years' worth of new approved cancer drugs has cast considerable doubt on their effectiveness and ability to improve a patient's quality of life.

Given the toxicity and expense of cancer drugs, patients should be exposed only "when they can reasonably expect an improvement in survival or quality of life", said Prasad.

Of 23 indications whose survival benefit could be scored with the ESMO-MCBS tool, the benefit was judged to be clinically meaningful in less than half (48%).

"While the European Medicines Agency (EMA) decides which new drugs are safe to be sold in Europe, it's national bodies like Nice (National Institute for Health and Care Excellence) that decide which drugs should be made available to patients".

"The fact that so numerous new drugs on the market lack good evidence that they improve patient outcomes puts governments in a hard position when it comes to deciding which treatments to fund", she writes.

"When there were survival gains over existing treatment options or placebo, they were often marginal".

"The fact that so numerous new drugs on the market lack good evidence that they improve patient outcomes puts governments in a hard position when it comes to deciding which treatments to fund", she said.

He said most cancer drugs - which cost about $100,000 per year of treatment - are being approved based on "flimsy or untested" initial measures and declared that the regulatory system was "broken".

This situation has negative implications for patients and public health - they concluded.

When the cancer in United Kingdom was presented in numbers it was found that 10000 number of lives which could be saved with earlier diagnosis, 352197 number of people diagnosed with cancer each year (2013), 161823 are the annual deaths from cancer (2012), 50% chance of living at least 10 years after cancer diagnosis as of 2010-2011. "But regulatory sanctioning of a comparator that lacks robust evidence of efficacy, means the cycle of weak evidence and uncertainty continues".

"We were quite surprised about the high proportion of drugs entering the market without evidence", said Huseyin Naci, of the London School of Economics and Political Science, one of the study's authors.

But she said that even though many new drugs may only extend patients' lives a few weeks or months, such gains can be worthwhile. Companies often create a lot of hype around their proclaimed benefits.

The research "paint (s) a sobering picture", wrote Vinay Prasad, an assistant professor of medicine at the Oregon Health and Science University, in an accompanying editorial.

Share

Advertisement

Related Posts

PH military rescues at least 17 hostages in Marawi
At least 17 hostages were rescued by the military in Marawi City on Wednesday, sources told ABS-CBN News. Nine of the hostages were men and eight were women.

NLDS: Kyle Hendricks to start Game 1 vs. Nationals
He also started its previous postseason game, helping the Cubs win in Cleveland in Game 7 for their first championship since 1908. He is 2-2 with a 2.67 ERA in five career starts against Washington. "The torch was kinda passed to me to do that".

Year-old girl 'raped' inside toilet of Delhi school
A case of rape has been registered under several sections of Protection of Children from Sexual Offences Act (POCSO). The incident reportedly took place inside the school toilet where the girl was assaulted by housekeeping staff.

Are Hedge Funds Betting Against Applied Optoelectronics, Inc. (AAOI)?
BidaskClub raised Applied Optoelectronics from a "hold" rating to a "buy" rating in a research note on Wednesday, July 12th. In the most updated research from a number of analysts on Wall Street, the company gets 7 Buys and 2 Sell among 9 analysts.

Audi Sport wants to have 16 models by 2020
Currently, Audi Sport already has a total of 11 RS models, and is set to increase to 16 by 2020. Audi Sport is also responsible for the S8 Plus, but that's apparently excluded from the tally.

Microsoft's (MSFT) "Neutral" Rating Reiterated at Atlantic Securities
After $0.34 actual EPS reported by Ares Capital Corporation for the previous quarter, Wall Street now forecasts 2.94% EPS growth. Tocqueville Asset Management Lp bought 1.67 million shares as the company's stock declined 11.27% while stock markets rallied.

Are Analysts Bullish KAZ Minerals PLC (LON:KAZ) After Last Week?
Looking further, the MF Rank (aka the Magic Formula) is a formula that pinpoints a valuable company trading at a good price. The Magic Formula was introduced in a book written by Joel Greenblatt, entitled, "The Little Book that Beats the Market".

England star Harry Kane: 'Being captain will not change how I play'
The England setup are attempting similar tweaks to enliven the customary routine to eke more from those at their disposal. So, over the past year or so, I've made them on the nutrition side. "I still eat what I was eating, nothing really new".

USA private sector adds 135000 jobs in September: ADP
On the flip side, jobs fell in the trade/transportation/utilities and information sectors, down by 18,000 and 11,000 respectively. Wednesday's ADP employment report threw up the same number of questions as it solved around USA jobs numbers in September.

Major League Baseball playoffs: Cubs choose Kyle Hendricks to start Game 1 vs. Nats
According to Jon Heyman of FanRag Sports , Jake Arrieta (hamstring) is aiming to start Game 3 of the NLDS against the Nationals . Twice, in both 2014 and again past year , they had four days between the end of the regular season and the postseason opener.

© 2015 . All Rights reserved.