"Of course we can't neglect the performance after that - we have to keep it in mind - but we have another game midweek when we can prove ourselves again".
But with each of them impressing whenever given opportunities, the system conundrum will only grow in the long term.
Pep Guardiola demands a lot of his players and Otamendi played on Saturday as if he was trying to flick through a folder of Pep instructions he had brought with him on to the pitch, while simultaneously also attempting to defend against the pace of Salah.
While Mane's red card sparked debate widely over social media, it all boils down to the referee's decision in the end.
But Jon Moss' decision to dismiss Mane has split opinion. "It's always risky", Mignolet added.
Without it, Trent Alexander-Arnold struggled at right-back.
After supplying the Argentine with a delightful ball, he then turned provider to his striker partner Gabriel Jesus.
The best was still to come from City's perspective, with Sane - on for Jesus, substituted with an eye on Wednesday's Champions League match at Feyenoord - putting the finishing touch on a flowing move before adding a fifth by arrowing a stunning left-footed strike into the top corner.
Moss was criticised for showing the red, but he seemingly had little choice with the challenge deemed serious foul play. Intent is irrelevant and it was both unsafe and reckless, so the referee had no choice. Liverpool had lost their most important player, a player whose powerful running and willingness may define the Klopp era. City fans loved his Tweet. Subs: Oxlade-Chamberlain 5, Milner 6, Solanke 5.
The Dutchman said: "You hope it never happens again but things can happen in a game and we must make sure, if it happens again, we do better with 10 men than we did".