'Liquid biopsy' spots early-stage cancers in blood

Share
'Liquid biopsy' spots early-stage cancers in blood

A test that scans blood for tumour-specific DNA identified early-stage cancer in more than half of 138 patients with the disease, United States researchers reported on Wednesday, marking a new milestone in the rush for so-called "liquid biopsies".

Note that the study adds to the growing volume of information about "liquid biopsies" for cancer diagnosis and other potential applications in cancer management.

Researchers behind the early-stage test hope it could be used to identify cancers at a stage when patients have a better chance at survival.

Just by looking at their blood, the researchers were able to identify 62 percent of the people with stage one cancer, fifty percent of the overall colon cancer patients, and 90 percent of the colon cancer patients with stage two, three or four.

The test detected stage 1 or 2 colon, breast, lung or ovarian cancers between 59 percent and 71 percent of the time when assessing 200 patients previously diagnosed with cancer, researchers found.

"The survival difference between late stage and early stage disease in these cancers would account for more than a million lives each year worldwide", Velculescu said.

Acknowledging that "a lot of work in liquid biopsies in general" is ongoing, Velculescu pointed to distinguishing features of the study.

Cancer patients had more of this DNA in their blood, the team found. "There are a number of confounding errors that can come up". The genes were sequenced in 100 of the patients and 82 of them showed the same mutations in blood samples as well as in the tumour tissue samples. It was even more accurate in finding late-stage cancers, but the goal would be to catch cancer in its earliest, easiest-to-treat stage.

Many well-established cancer biomarkers also occur in the absence of cancer - such as cancer antigen (CA) 125, CA-19, carcinoembryonic antigen, and prostate-specific antigen. These pieces are called cell-free circulating tumor DNA (ctDNA).

A team of oncologists at Johns Hopkins Kimmel Cancer Center found that dying tumor cells release small bits of their DNA into a sufferer's blood which can be tested.

Investigators analyzed plasma samples from a total of 194 patients, consisting of 45 patients with breast cancer, 42 with colorectal cancer, 65 with lung cancer, and 42 with ovarian cancer. These were untreated patients who had localized or metastatic disease at stages I and II.

Each blood sample was screened with a panel of 58 genes commonly associated with a variety of cancers. While concentrations of cfDNA were average of 7 ng/ml in healthy participants, it was around 29 ng/ml in cancer patients. The detection rate increased into the 90s for the later stages of tumors, based on the tumor type, the results show. In the colorectal subgroup, the test predicted cancer in four of eight patients with stage I disease, eight of nine with stage II disease, nine of 10 with stage III, and 14 of 15 with stage IV.

To check the blood test's ability to weed out healthy people, the researchers also analyzed blood from 44 volunteers without cancer.

A new Johns Hopkins study outlines a potentially game-changing screening methodology to catch some of the most common cancers at their earliest stages.

Scientists at King's College London think the new imaging technique will allow them to identify women whose cancer is likely to spread into their lungs, allowing them to use intensive treatments earlier to stop the spread.

The study was supported by the NIH and multiple philanthropic, nonprofit, and governmental sources.

Velculescu disclosed relevant relationships with Personal Genome Diagnostics and Ignyta, as well as patent/royalty interests.

Share

Advertisement

Related Posts

Tesoro Logistics LP (NYSE:ANDX) Coverage Initiated by Analysts at Morgan Stanley
The research group scores the sentiment of news coverage by monitoring more than 20 million blog and news sources in real-time. The company had revenue of $413 million for the quarter, compared to the consensus estimate of $441.69 million.

Pink asks "What About Us?" in politically-charged new video
Pink tweeted that she and her band celebrated the news, saying they felt "blessed beyond belief" for the honor from the Video Music Awards.

Weather delays start of Camping World Truck Series' UNOH 200 at Bristol
As far as bubble drivers go, Chase Elliott, Jamie McMurray and Kenseth are in on merit but no spot is safe without a win. I've run the Xfinity Series and (Monster Energy) Cup (Series), so I've got a good amount of experience there to lean on.

Images of Bengaluru after heaviest downpour since 1890
The Bellandur Lake, the largest of the 262 lakes and tanks in the city, was seen covered in toxic foam after the heavy downpour. Rains from Monday night to Tuesday morning flooded major roads and drainage water entered houses in low-lying areas.

Bannon in limbo as Trump urged to sack him
Bannon added that "the economic war with China is everything", arguing the United States needs to be "maniacally focused on that". Of his adversaries in the State Department and Defense who want to enlist China's help Bannon said "they're wetting themselves".

LeBron James' Production Company Developing Series About Madam CJ Walker
The series will be based on the book " On Her Own Ground ", written by the great-great-granddaughter of Walker, A'Lelia Bundles. However, everything changed following Walker's discovery of a revolutionary hair care formula for black women.

9-year-old Pinay brings 'America's Got Talent' judge to tears
The other judges had similar glowing reviews for Hale's performance, with Simon Cowell calling her a "very, very special girl". Five years later, this tiny singer was about to show the world just how far she had come since that day she became ill.

Home buyers who have paid money should get their flats: Jailtey
The IRP has instructed the homebuyers, employees and creditors to file their respective claims against Jaypee group by August 24. The government is also reportedly considering sale of the company's assets to raise money to complete the project.

Nabors Industries Ltd. (NYSE:NBR) Shares Bought by Sasco Capital Inc
Finally, Citigroup Inc. reaffirmed a "buy" rating on shares of Nabors Industries in a research report on Wednesday, May 10th. The stock of Nabors Industries Ltd . (NYSE:NBR) has "Buy" rating given on Thursday, September 15 by DA Davidson.

British Columbia 2017 wildfire season is officially the worst on record
A cold front Friday will bring cooler temperatures but also gusts and likely thunderstorms. The amount of land lost to flames is equivalent to 79 cities the same size of Vancouver.

© 2015 ExpressNewsline. All Rights reserved.