The Chief Executive of Afghanistan, Abdullah Abdullah, said the attack had been carried out in co-ordination with his government and "great care had been taken to avoid civilian harm".
However, Mr Karazi, who served as Afghan president up until 2014, was left seething with the US' deployment of such a "dangerous" weapon.
In March, US forces conducted 79 "counterterror strikes" against Islamic State targets in Nangarhar, killing as many as 200 militants, according to the USA military command in Kabul.
The non-nuclear bomb is meant to destroy a complex cave and tunnel system that are allegedly being used by the Islamic State (ISIS) forces.
Nangarhar provincial spokesman Attaullah Khogyani gave a toll of 90, far higher than the initial toll of 36 IS fighters given by Afghan officials.
A ministry of defence official had said on Friday that the number of dead could rise as officials assessed the bomb site in Achin district. Besides, Pakistan has been the training ground for terrorists who took part in many terror attacks internationally, including the ill-famed World Trade Centre attack in NY. No civilians were reported dead in the bombing.
"I vehemently and in strongest words condemn the dropping of the latest weapon, the largest non-nuclear #bomb, on Afghanistan by U.S.", he tweeted soon after reports of the bombing emerged. During the final stages of testing in 2013, military officials considered the weapon to be useful in "psychological operations". It is upon us, Afghans, to stop the #USA. He added that the action amounted to what he termed "national treason".
Thursday's strike marked the first time the munition had been used in combat, and it became the most powerful bomb used in Afghanistan to date.
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No civilian casualties have been reported yet by the USA or Afghan military. "This is a country of free speech".
USA forces in Afghanistan on Thursday struck an Islamic State tunnel complex.
Islamic State deny any of its soldiers were killed by the blast.
U.S. President Donald Trump April 13 called the bombing "another successful job".
Ghani has failed to build the kind of domestic following that Karzai still has despite stepping down in 2014. United States and Afghan forces had been unable to advance because ISIS - which has expanded into Afghanistan in recent years - had mined the area with explosives.
"I chose to get America off my soil", he said.
"Using this massive bomb can not be justified and will leave a material and psychological impact on our people", the armed group said in a statement.
The top USA military commander in Afghanistan, General John Nicholson, had said the decision to use the bomb was purely tactical, and made as part of the campaign against IS-linked fighters. The U.S. has more than 8,000 USA troops in Afghanistan, training local forces and conducting counterterrorism operations.