Hull gave its Premier League survival hopes a lift and pushed Middlesbrough closer to the drop with a 4-2 victory in a pulsating game between two relegation-threatened teams on Wednesday.
The game started at a breathtaking pace, typical with both sides in relegation trouble, and it was Middlesbrough who drew first blood when Negredo slid home Adama Traore's cross in the fifth minute.
Middlesbrough are the league's lowest scorers with 22 goals and have relied heavily on their defence to secure points this season, but their back four was left brutally exposed at Hull when an emphasis was placed on attack. Not this one, however, as Hull began the match on the front foot and had the ball in the net within three minutes as Markovic squared the ball to Niasse, who had strayed offside, so his goal was disallowed.
Middlesbrough (4-4-2): Valdes 6; Barragan 6, Ayala 6, Gibson 5, Husband 6 (Guedioura 59, 5); Traore 7, Clayton 6, De Roon 6, Downing 6; Gestede 5 (Stuani 81), Negredo 7 (Bamford 71, 5).
The home side seemed to wake up from their slumber and responded seven minutes later as Markovic poked the ball into the back of the net after Andrew Robertson's cross was deflected into the path of the oncoming Serbian.
Alfred N'Diaye hooked the ball forward and Hernandez's headed pass fell invitingly to Niasse, who buried his shot under Boro goalkeeper Victor Valdes from 12 yards. Alvaro Negredo put Boro infront, sliding to score Boro's first away goal of the year.
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Marten De Roon scored on the stroke of half-time from an offside position to make the score 3-2, but Harry Maguire's header from a set-piece in the second half effectively killed the game off.
Boro were stunned and needed some invention to get back in the game and Rudy Gestede almost provided that but he saw his header tipped onto the crossbar by keeper Eldin Jakupovic.
The visitors did get one back in controversial circumstances in time added-on at the end of the first-half.
Nobody picked up Maguire at the far post, allowing him to power Robertson's deep free-kick delivery across goal and in with a stunning header.
The Tigers suffered an early blow in the second half when Hernandez was forced off with an injury, with Evandro coming on in his place.
That suited the Tigers and a fourth goal came on 69 minutes. Their total of 23 points is five behind that of Swansea City in 18th and eight points from safety.