A few injury questions aside (Marcos Alonso, David Luiz both appeared to be carrying knocks after Saturday's game) we will probably choose to go with that tried and trusted starting eleven.
There are not many teams that can stop this Chelsea side but playing at home, Pochettino will hope that his side can halt their winning run.
We had to wait until the second-half for the breakthrough, with Jordon Ibe threading through Callum Wilson one-on-one with goalkeeper Petr Cech, before firing the ball into the far corner on the hour mark.
Despite Chelsea's excellent run, Tottenham's form coupled with the fact that they have home advantage suggests that it is an extremely hard game to call, so it perhaps would not be the biggest surprise if Collymore's prediction comes to fruition.
"That's what I think would take a Tottenham side to the title".
"That's why I don't like it when they ask me, either".
Veteran Matt Cassel to start for Titans with Mariota out
Had the Titans (8-7) defeated Jacksonville last week, the game against the Texans would have decided the AFC South victor . The 8-7 Titans will be without star quarterback player Marcus Mariota .
Tottenham Hotspur face the current Premier League leaders Chelsea at White Hart Lane on Wednesday.
The Blues could do the league double against Spurs for the first time since 2005-06.
Chelsea came from two goals down to draw 2-2 with Spurs in a foul-tempered match at Stamford Bridge in May - a result that ended Spurs' title hopes and confirmed Leicester City as Premier League champions.
They have won four league games in a row, scoring 13 goals in the process and conceding just three.
Since his return, Kane has scored 10 goals in 11 games and he attaches a special significance to Chelsea, against whom he scored twice in Tottenham's resounding 5-3 victory in this fixture two years ago. They would equal Arsenal's English top-flight record of 14 successive wins between February-August 2002 (over two seasons).
Probability of away win: 29%.